{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T21:57:32Z","timestamp":1789595852863,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2009,5,28]],"date-time":"2009-05-28T00:00:00Z","timestamp":1243468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2009,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Among rheumatoid arthritis (RA) patients who have had the disease for 10 years, more than half have focal erosions, and the risk of fracture is doubled. However, there is little information about the potential relationship between focal erosions and bone mineral density (BMD). The aim of this study was to determine whether lower BMD is associated with higher erosion scores among patients with RA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We enrolled 163 postmenopausal women with RA, none of whom were taking osteoporosis medications. Patients underwent dual x\u2010ray absorptiometry at the hip and spine and hand radiography, and completed a questionnaire. The hand radiographs were scored using the Sharp method, and the relationship between BMD and erosions was measured using Spearman's correlation coefficients and adjusted linear regression models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients had an average disease duration of 13.7 years, and almost all were taking a disease\u2010modifying antirheumatic drug. Sixty\u2010three percent were rheumatoid factor (RF) positive. The median modified Health Assessment Questionnaire score was 0.7, and the average Disease Activity Score in 28 joints was 3.8. The erosion score was significantly correlated with total hip BMD (r = \u22120.33,<jats:italic>P<\/jats:italic>&lt; 0.0001), but not with lumbar spine BMD (r = \u22120.09,<jats:italic>P<\/jats:italic>= 0.27). Hip BMD was significantly lower in RF\u2010positive patients versus RF\u2010negative patients (<jats:italic>P<\/jats:italic>= 0.02). In multivariable models that included age, body mass index, and cumulative oral glucocorticoid dose, neither total hip BMD nor lumbar spine BMD was significantly associated with focal erosions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results suggest that hip BMD is associated with focal erosions among postmenopausal women with RA, but that this association disappears after multivariable adjustment. While BMD and erosions may be correlated with bone manifestations of RA, their relationship is complex and influenced by other disease\u2010related factors.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.24551","type":"journal-article","created":{"date-parts":[[2009,5,28]],"date-time":"2009-05-28T11:35:01Z","timestamp":1243510501000},"page":"1624-1631","source":"Crossref","is-referenced-by-count":58,"title":["The relationship between focal erosions and generalized osteoporosis in postmenopausal women with rheumatoid arthritis"],"prefix":"10.1002","volume":"60","author":[{"given":"Daniel H.","family":"Solomon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel S.","family":"Finkelstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Shadick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meryl S.","family":"LeBoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl S.","family":"Winalski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Stedman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Glass","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Alan","family":"Brookhart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E.","family":"Weinblatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen M.","family":"Gravallese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,5,28]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.10897"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-857X(05)70201-5"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)06075-5"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.22117"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.bor.0000127824.42507.68"},{"key":"e_1_2_6_7_2","first-page":"943","article-title":"Identification of cell types responsible for bone resorption in rheumatoid arthritis and juvenile rheumatoid arthritis","volume":"152","author":"Gravallese EM","year":"1998","journal-title":"Am J Pathol"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2003.015065"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63144-6"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.22549"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780281203"},{"key":"e_1_2_6_12_2","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/S0003-4967(24)43379-7","article-title":"Radiographic scoring methods as outcome measures in rheumatoid arthritis: properties and advantages","volume":"60","author":"Boini S","year":"2001","journal-title":"Ann Rheum Dis"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keg072"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199210000-00004"},{"key":"e_1_2_6_15_2","first-page":"2350","article-title":"Relation between body mass index and radiological progression in patients with rheumatoid arthritis","volume":"30","author":"Kaufmann J","year":"2003","journal-title":"J Rheumatol"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.10616"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1080\/03009740510017986"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh385"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1177\/028418517701800415"},{"key":"e_1_2_6_20_2","first-page":"2590","article-title":"Reduced bone mineral density in early rheumatoid arthritis is associated with radiological joint damage at baseline and after 2 years in women","volume":"30","author":"Forslind K","year":"2003","journal-title":"J Rheumatol"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.21405"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.086348"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.063834"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1186\/ar1740"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.23784"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2007.07.001"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kei082"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.073817"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa044459"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.23417"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.24551","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.24551","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,9]],"date-time":"2025-02-09T18:59:06Z","timestamp":1739127546000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.24551"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5,28]]},"references-count":29,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2009,6]]}},"alternative-id":["10.1002\/art.24551"],"URL":"https:\/\/doi.org\/10.1002\/art.24551","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,5,28]]}}}