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Pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated by using the random\u2010effects model. Subgroup meta\u2010analyses and meta\u2010regression analyses were undertaken to investigate the effects of selected study\u2010level parameters on the pooled OR. Heterogeneity was assessed using the I<jats:sup>2<\/jats:sup> statistic. Pooled results were used to calculate population\u2010attributable risks (PAR) for BD in relationship to <jats:italic>HLA\u2013B51\/B5<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 4,800 patients with BD and 16,289 controls from 78 independent studies (published 1975\u20132007) were selected. The pooled OR of <jats:italic>HLA\u2013B51\/B5<\/jats:italic> allele carriers to develop BD compared with noncarriers was 5.78 (95% CI 5.00\u20136.67), with moderate between\u2010study heterogeneity (I<jats:sup>2<\/jats:sup> = 61%). The subgroup analyses stratifying studies by geographic locations (Eastern Asia, Middle East\/North Africa, Southern Europe, Northern\/Eastern Europe) yielded consistent OR ranges (5.31\u20137.20), with I<jats:sup>2<\/jats:sup> ranges of 52\u201370%. Univariate random\u2010effects meta\u2010regression indicated the percentage of male BD cases (<jats:italic>P<\/jats:italic> = 0.008) as a source of heterogeneity. The PAR within the various geographic areas were estimated at 32\u201352%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The strength of the association between BD and <jats:italic>HLA\u2013B51\/B5<\/jats:italic>, and its consistency across populations of various ethnicities, lends further support to this allele being a primary and causal risk determinant for BD. Variations according to sex support an interaction of this allele with BD characteristics.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.24642","type":"journal-article","created":{"date-parts":[[2009,9,29]],"date-time":"2009-09-29T10:28:11Z","timestamp":1254220091000},"page":"1287-1296","source":"Crossref","is-referenced-by-count":426,"title":["<i>HLA\u2013B51\/B5<\/i> and the risk of Beh\u00e7et's disease: A systematic review and meta\u2010analysis of case\u2013control genetic association studies"],"prefix":"10.1002","volume":"61","author":[{"given":"Mathilde","family":"de Menthon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael 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