{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T12:00:39Z","timestamp":1791115239644,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2009,10,29]],"date-time":"2009-10-29T00:00:00Z","timestamp":1256774400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Minnesota Partnership for Biotechnology and Medical Genomics"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2009,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Up\u2010regulation of whole blood type I interferon (IFN)\u2013driven transcripts and chemokines has been described in a number of autoimmune diseases. An IFN gene expression \u201csignature\u201d is a candidate biomarker in patients with dermatomyositis (DM). This study was performed to evaluate the capacity of IFN\u2010dependent peripheral blood gene and chemokine signatures and levels of proinflammatory cytokines to serve as biomarkers for disease activity in adult and juvenile DM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Peripheral blood samples and clinical data were obtained from 56 patients with adult or juvenile DM. The type I IFN gene signature in the whole blood of patients with DM was defined by determining the expression levels of 3 IFN\u2010regulated genes (IFIT1, G1P2, and IRF7) using quantitative real\u2010time reverse transcription\u2013polymerase chain reaction. Multiplexed immunoassays were used to quantify the serum levels of 4 type I IFN\u2013regulated chemokines (IFN\u2010inducible T cell \u03b1 chemoattractant, IFN\u03b3\u2010inducible 10\u2010kd protein, monocyte chemotactic protein 1 [MCP\u20101], and MCP\u20102) and the serum levels of other proinflammatory cytokines, including interleukin\u20106 (IL\u20106).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>DM disease activity correlated significantly with the type I IFN gene signature (r = 0.41, <jats:italic>P<\/jats:italic> = 0.007) and with the type I IFN chemokine signature (r = 0.61, <jats:italic>P<\/jats:italic> &lt; 0.0001). Furthermore, the serum levels of IL\u20106 were significantly correlated with disease activity (r = 0.45, <jats:italic>P<\/jats:italic> = 0.001). In addition, correlations between the serum levels of IL\u20106 and both the type I IFN gene signature (r = 0.47, <jats:italic>P<\/jats:italic> &lt; 0.01) and the type I IFN chemokine signature (r = 0.71, <jats:italic>P<\/jats:italic> &lt; 0.0001) were detected in patients with DM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results suggest that serum IL\u20106 production and the type I IFN gene signature are candidate biomarkers for disease activity in adult and juvenile DM. Coregulation of the expression of IFN\u2010driven chemokines and IL\u20106 suggests a novel pathogenic linkage in DM.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.24936","type":"journal-article","created":{"date-parts":[[2009,10,29]],"date-time":"2009-10-29T21:16:37Z","timestamp":1256850997000},"page":"3436-3446","source":"Crossref","is-referenced-by-count":219,"title":["Interleukin\u20106 and type I interferon\u2013regulated genes and chemokines mark disease activity in dermatomyositis"],"prefix":"10.1002","volume":"60","author":[{"given":"Hatice","family":"Bilgic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven R.","family":"Ytterberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shreyasee","family":"Amin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly 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