{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T22:20:17Z","timestamp":1779920417233,"version":"3.53.1"},"reference-count":22,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2009,10,29]],"date-time":"2009-10-29T00:00:00Z","timestamp":1256774400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001505","name":"Health Research Council of New Zealand","doi-asserted-by":"crossref","award":["08\/075BR"],"award-info":[{"award-number":["08\/075BR"]}],"id":[{"id":"10.13039\/501100001505","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100008247","name":"University of Otago","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008247","id-type":"DOI","asserted-by":"crossref"}]},{"name":"New Zealand National Heart Foundation Research Fellowship"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2009,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To examine the role of genetic variation in the renal urate transporter <jats:italic>SLC2A9<\/jats:italic> in gout in New Zealand sample sets of M\u0101ori, Pacific Island, and Caucasian ancestry and to determine if the M\u0101ori and Pacific Island samples could be useful for fine\u2010mapping.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients (n= 56 M\u0101ori, 69 Pacific Island, and 131 Caucasian) were recruited from rheumatology outpatient clinics and satisfied the American College of Rheumatology criteria for gout. The control samples comprised 125 M\u0101ori subjects, 41 Pacific Island subjects, and 568 Caucasian subjects without arthritis. <jats:italic>SLC2A9<\/jats:italic> single\u2010nucleotide polymorphisms <jats:italic>rs16890979<\/jats:italic> (V253I), <jats:italic>rs5028843, rs11942223,<\/jats:italic> and <jats:italic>rs12510549<\/jats:italic> were genotyped (possible etiologic variants in Caucasians).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Association of the major allele of <jats:italic>rs16890979<\/jats:italic>, <jats:italic>rs11942223<\/jats:italic>, and <jats:italic>rs5028843<\/jats:italic> with gout was observed in all sample sets (<jats:italic>P<\/jats:italic> = 3.7 \u00d7 10<jats:sup>\u22127<\/jats:sup>, 1.6 \u00d7 10<jats:sup>\u22126<\/jats:sup>, and 7.6 \u00d7 10<jats:sup>\u22125<\/jats:sup> for <jats:italic>rs11942223<\/jats:italic> in the M\u0101ori, Pacific Island, and Caucasian samples, respectively). One 4\u2010marker haplotype (1\/1\/2\/1; more prevalent in the M\u0101ori and Pacific Island control samples) was not observed in a single gout case.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our data confirm a role of <jats:italic>SLC2A9<\/jats:italic> in gout susceptibility in a New Zealand Caucasian sample set, with the effect on risk (odds ratio &gt;2.0) greater than previous estimates. We also demonstrate association of <jats:italic>SLC2A9<\/jats:italic> with gout in samples of M\u0101ori and Pacific Island ancestry and a consistent pattern of haplotype association. The presence of both alleles of <jats:italic>rs16890979<\/jats:italic> on susceptibility and protective haplotypes in the M\u0101ori and Pacific Island sample is evidence against a role for this nonsynonymous variant as the sole etiologic agent. More extensive linkage disequilibrium in M\u0101ori and Pacific Island samples suggests that Caucasian samples may be more useful for fine\u2010mapping.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.24938","type":"journal-article","created":{"date-parts":[[2009,10,29]],"date-time":"2009-10-29T21:16:37Z","timestamp":1256850997000},"page":"3485-3492","source":"Crossref","is-referenced-by-count":97,"title":["Role of the urate transporter <i>SLC2A9<\/i> gene in susceptibility to gout in New Zealand M\u0101ori, Pacific Island, and Caucasian case\u2013control sample sets"],"prefix":"10.1002","volume":"60","author":[{"given":"Jade E.","family":"Hollis\u2010Moffatt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Dalbeth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilyn E.","family":"Merriman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Topless","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chloe","family":"Waddell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Gow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew A.","family":"Harrison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Highton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter B. B.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa K.","family":"Stamp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony R.","family":"Merriman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,10,29]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.56.1.22"},{"key":"e_1_2_7_3_2","first-page":"U2503","article-title":"Prevention of colchicine toxicity in patients with gout","volume":"120","author":"Dalbeth N","year":"2007","journal-title":"N Z Med J"},{"key":"e_1_2_7_4_2","first-page":"1646","article-title":"Dose adjustment of allopurinol according to creatinine clearance does not provide adequate control of hyperuricaemia in patients with gout","volume":"33","author":"Dalbeth N","year":"2006","journal-title":"J Rheumatol"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kem246"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.39.5.417"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/23.4.276"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/33.10.932"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.21499"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2006.07.030"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61343-4"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.0030194"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-0349"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.107"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.23752"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.106"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2007.11.001"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0001948"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0050197"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780200320"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1168953"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.22474"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.070755"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.24938","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.24938","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T05:44:07Z","timestamp":1697003047000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.24938"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10,29]]},"references-count":22,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2009,11]]}},"alternative-id":["10.1002\/art.24938"],"URL":"https:\/\/doi.org\/10.1002\/art.24938","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,10,29]]}}}