{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:15:04Z","timestamp":1792034104994,"version":"4.4.0"},"reference-count":54,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2009,11,30]],"date-time":"2009-11-30T00:00:00Z","timestamp":1259539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2009,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the role of matrix metalloproteinase 13 (MMP\u201013; collagenase 3) in osteoarthritis (OA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>OA was surgically induced in the knees of MMP\u201013\u2013knockout mice and wild\u2010type mice, and mice were compared. Histologic scoring of femoral and tibial cartilage aggrecan loss (0\u20133 scale), erosion (0\u20137 scale), and chondrocyte hypertrophy (0\u20131 scale), as well as osteophyte size (0\u20133 scale) and maturity (0\u20133 scale) was performed. Serial sections were stained for type X collagen and the MMP\u2010generated aggrecan neoepitope DIPEN.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Following surgery, aggrecan loss and cartilage erosion were more severe in the tibia than femur (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.01) and tibial cartilage erosion increased with time (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.05) in wild\u2010type mice. Cartilaginous osteophytes were present at 4 weeks and underwent ossification, with size and maturity increasing by 8 weeks (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.01). There was no difference between genotypes in aggrecan loss or cartilage erosion at 4 weeks. There was less tibial cartilage erosion in knockout mice than in wild\u2010type mice at 8 weeks (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.02). Cartilaginous osteophytes were larger in knockout mice at 4 weeks (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.01), but by 8 weeks osteophyte maturity and size were no different from those in wild\u2010type mice. Articular chondrocyte hypertrophy with positive type X collagen and DIPEN staining occurred in both wild\u2010type and knockout mouse joints.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings indicate that structural cartilage damage in a mouse model of OA is dependent on MMP\u201013 activity. Chondrocyte hypertrophy is not regulated by MMP\u201013 activity in this model and does not in itself lead to cartilage erosion. MMP\u201013 deficiency can inhibit cartilage erosion in the presence of aggrecan depletion, supporting the potential for therapeutic intervention in established OA with MMP\u201013 inhibitors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.25002","type":"journal-article","created":{"date-parts":[[2009,11,30]],"date-time":"2009-11-30T13:13:25Z","timestamp":1259586805000},"page":"3723-3733","source":"Crossref","is-referenced-by-count":600,"title":["Matrix metalloproteinase 13\u2013deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development"],"prefix":"10.1002","volume":"60","author":[{"given":"C. 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