{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:31:46Z","timestamp":1786977106216,"version":"build-2736575974"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2010,1,28]],"date-time":"2010-01-28T00:00:00Z","timestamp":1264636800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis & Rheumatism"],"published-print":{"date-parts":[[2010,2]]},"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:title>\n Previous studies of polyarteritis nodosa (PAN) included patients with microscopic polyangiitis, because these entities were not distinguished prior to the Chapel Hill Consensus Conference (CHCC). This study was undertaken to describe the main characteristics of and long\u2010term outcomes in patients with well\u2010characterized PAN diagnoses.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We conducted a systematic retrospective study of 348 patients who were diagnosed as having PAN between March 1963 and October 2005, were registered in the French Vasculitis Study Group database, and satisfied the American College of Rheumatology and CHCC criteria. Patient characteristics and outcomes were analyzed and compared according to hepatitis B virus (HBV) status.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n At diagnosis, the mean \u00b1 SD age was 51.2 \u00b1 17.3 years. The most frequent findings were general symptoms (93.1%), neurologic manifestations (79%), skin involvement (49.7%), abdominal pain (35.6%), and hypertension (34.8%); 66.2% had renal artery microaneurysms; 70.1% had histologically proven PAN. Patients with HBV\u2010related PAN (n = 123) had more frequent peripheral neuropathy, abdominal pain, cardiomyopathy, orchitis, and hypertension compared with patients with non\u2013HBV\u2010related PAN (n = 225). During a mean \u00b1 SD followup of 68.3 \u00b1 63.5 months, 76 patients (21.8%) relapsed (63 with non\u2013HBV\u2010related PAN [28%] versus 13 with HBV\u2010related PAN [10.6%];\n P<\/jats:italic>\n < 0.001); 86 patients (24.7%) died (44 with non\u2013HBV\u2010related PAN [19.6%] versus 42 with HBV\u2010related PAN [34.1%];\n P<\/jats:italic>\n = 0.003). Five\u2010year relapse\u2010free survival rates were 59.4% (95% confidence interval [95% CI] 52.6\u201367.0) versus 67.0% (95% CI 58.5\u201376.8) for non\u2013HBV\u2010related PAN and HBV\u2010related PAN, respectively. Multivariate analysis retained age >65 years, hypertension, and gastrointestinal manifestations requiring surgery or at least consultation with a surgeon as independent predictors of death, whereas patients with cutaneous manifestations or non\u2013HBV\u2010related PAN had a higher risk of relapse.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Our findings indicate that the rate of mortality from PAN remains high, especially for the elderly, and relapses do occur, particularly in patients with non\u2013HBV\u2010related PAN with cutaneous manifestations.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/art.27240","type":"journal-article","created":{"date-parts":[[2010,1,28]],"date-time":"2010-01-28T12:58:15Z","timestamp":1264683495000},"page":"616-626","source":"Crossref","is-referenced-by-count":500,"title":["Clinical features and outcomes in 348 patients with polyarteritis nodosa: A systematic retrospective study of patients diagnosed between 1963 and 2005 and entered into the French vasculitis study group database"],"prefix":"10.1002","volume":"62","author":[{"given":"Christian","family":"Pagnoux","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rapha\u00e8le","family":"Seror","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corneliu","family":"Henegar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfred","family":"Mahr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Le Guern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Bienvenu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Mouthon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lo\u00efc","family":"Guillevin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,1,28]]},"reference":[{"key":"e_1_2_7_2_2","first-page":"484","article-title":"Ueber eine bisher nicht beschriebene eigenth\u00fcmliche Arterienerkrankung (Periarteritis nodosa), die mit Morbus Brightii und rapid fortschreitender allgemeiner Muskell\u00e4hmung einhergeht","volume":"1","author":"Kussmaul A","year":"1866","journal-title":"Dtsch Arch Klin Med"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(67)90144-1"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(79)90634-X"},{"key":"e_1_2_7_5_2","first-page":"146","article-title":"Clinical features, prognosis, and response to treatment in polyarteritis","volume":"55","author":"Cohen RD","year":"1980","journal-title":"Mayo Clin Proc"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/27.4.258"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01947911"},{"key":"e_1_2_7_8_2","first-page":"175","article-title":"Kidney in periarteritis nodosa","volume":"17","author":"Davson J","year":"1948","journal-title":"Q J Med"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780370206"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199711203372106"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780330805"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)91147-X"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.10922"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.md.0000180792.80212.5e"},{"key":"e_1_2_7_15_2","first-page":"1522","article-title":"Periarteritis nodosa related to hepatitis B virus. 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