{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T22:18:40Z","timestamp":1790720320418,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2010,1,7]],"date-time":"2010-01-07T00:00:00Z","timestamp":1262822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2010,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To define the nature of structural bone changes in patients with rheumatoid arthritis (RA) compared with those in healthy individuals by using the novel technique of high\u2010resolution microfocal computed tomography (micro\u2010CT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Fifty\u2010eight RA patients and 30 healthy individuals underwent a micro\u2010CT scan of the proximal wrist and metacarpophalangeal joints. Bone lesions such as cortical breaks, osteophytes, and surface changes were quantified on 2\u2010dimensional (2\u2010D) slices as well as by using 3\u2010D reconstruction images, and exact localization of lesions was recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Micro\u2010CT scans could detect bone lesions &lt;0.5 mm in width or depth. Small erosions could be observed in healthy individuals and RA patients, whereas lesions &gt;1.9 mm in diameter were highly specific for RA. Cortical breaks were mostly found along the radial sites of the metacarpal heads. No significant difference in the presence of osteophytes between healthy individuals and RA patients was found. Cortical surface changes, presumably cortical thinning and fenestration, became evident from 3\u2010D reconstructions and were more pronounced in RA patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Micro\u2010CT allows exact detection of morphologic changes of juxtaarticular bone in healthy individuals and RA patients. Even healthy individuals occasionally show bone changes, but the severity of these lesions, with the exception of osteophytes, is greater in RA patients. Thus, micro\u2010CT allows accurate differentiation among physiologic bone changes in joints and among types of pathologic bone damage resulting from RA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.27252","type":"journal-article","created":{"date-parts":[[2010,1,7]],"date-time":"2010-01-07T12:55:19Z","timestamp":1262868919000},"page":"330-339","source":"Crossref","is-referenced-by-count":173,"title":["Periarticular bone structure in rheumatoid arthritis patients and healthy individuals assessed by high\u2010resolution computed tomography"],"prefix":"10.1002","volume":"62","author":[{"given":"Christian M.","family":"Stach","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"B\u00e4uerle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Englbrecht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Kronke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Engelke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Manger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Schett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,1,28]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"2344","article-title":"Predictive factors of 5\u2010year health assessment questionnaire disability in early rheumatoid arthritis","volume":"30","author":"Combe B","year":"2003","journal-title":"J Rheumatol"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01661"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2094"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.21548"},{"key":"e_1_2_6_6_2","first-page":"S20","article-title":"Joint damage and disability in rheumatoid arthritis: an updated systematic review","volume":"21","author":"Scott DL","year":"2003","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.081331"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310302"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2005.038513"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/39.2.122"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200109)44:9<2009::AID-ART349>3.0.CO;2-L"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keg327"},{"key":"e_1_2_6_13_2","first-page":"943","article-title":"Identification of cell types responsible for bone resorption in rheumatoid arthritis and juvenile rheumatoid arthritis","volume":"152","author":"Gravallese EM","year":"1998","journal-title":"Am J Pathol"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.60.10.924"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.59.3.223"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.10117"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.23945"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.11481"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.20484"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2008.09.014"},{"key":"e_1_2_6_21_2","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/S0003-4967(24)43379-7","article-title":"Radiographic scoring methods as outcome measures in rheumatoid arthritis: properties and advantages","volume":"60","author":"Boini S","year":"2001","journal-title":"Ann Rheum Dis"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.61.10.895"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199906)42:6<1232::AID-ANR21>3.0.CO;2-3"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200012)43:12<2762::AID-ANR16>3.0.CO;2-#"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1186\/ar1995"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.072520"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1186\/ar2378"},{"key":"e_1_2_6_28_2","first-page":"256","article-title":"Detection of erosions in the rheumatoid hand; 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