{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T03:44:12Z","timestamp":1792727052787,"version":"4.5.0"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2010,1,7]],"date-time":"2010-01-07T00:00:00Z","timestamp":1262822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2010,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>An increased risk of tuberculosis has been documented in humans treated with tumor necrosis factor \u03b1 (TNF\u03b1)\u2013neutralizing agents. In murine models, impaired signaling by TNF causes exacerbation of both acute and chronic infection associated with aberrant granuloma formation and maintenance. This study was undertaken to investigate immune modulation in the setting of TNF neutralization in primary and latent tuberculosis in a non\u2010human primate model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cynomolgus macaques 4 years of age or older were infected with <jats:italic>Mycobacterium tuberculosis<\/jats:italic> and subjected to clinical, microbiologic, immunologic, and radiographic examinations. Monkeys were classified as having active or latent disease 6\u20138 months after infection, based on clinical criteria. Monkeys used in acute infection studies were randomized to receive either adalimumab (prior to and during infection) or no treatment. Monkeys with latent infection that were randomized to receive TNF\u2010neutralizing agent were given either an inhibitor of soluble TNF, recombinant methionyl human soluble TNF receptor I (p55\u2010TNFRI), or adalimumab. Control monkeys with latent infection were given no treatment or saline. Data from previously studied monkeys with active or latent disease were also used for comparison.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Administration of TNF\u2010neutralizing agents prior to <jats:italic>M tuberculosis<\/jats:italic> infection resulted in fulminant and disseminated disease by 8 weeks after infection. Neutralization of TNF in latently infected cynomolgus macaques caused reactivation in a majority of animals as determined by gross pathologic examination and bacterial burden. A spectrum of dissemination was noted, including extrapulmonary disease. Surprisingly, monkeys that developed primary and reactivation tuberculosis after TNF neutralization had similar granuloma structure and composition to that of control monkeys with active disease. TNF neutralization was associated with increased levels of interleukin\u201012, decreased levels of CCL4, increased chemokine receptor expression, and reduced mycobacteria\u2010induced interferon\u2010\u03b3 production in blood but not in the affected mediastinal lymph nodes. Finally, the first signs of reactivation often occurred in thoracic lymph nodes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These findings have important clinical implications for determining the mechanism of TNF neutralization\u2013related tuberculosis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.27271","type":"journal-article","created":{"date-parts":[[2010,1,7]],"date-time":"2010-01-07T17:55:42Z","timestamp":1262886942000},"page":"340-350","source":"Crossref","is-referenced-by-count":211,"title":["Tumor necrosis factor neutralization results in disseminated disease in acute and latent <i>Mycobacterium tuberculosis<\/i> infection with normal granuloma structure in a cynomolgus macaque model"],"prefix":"10.1002","volume":"62","author":[{"given":"Philana 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