{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T02:35:10Z","timestamp":1789180510548,"version":"build-2803163510"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2010,1,13]],"date-time":"2010-01-13T00:00:00Z","timestamp":1263340800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2010,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>In contrast to rheumatoid arthritis (RA), the joint inflammation referred to as Jaccoud's arthritis that occurs in systemic lupus erythematosus (SLE) is nonerosive. Although the mechanism responsible is unknown, the antiosteoclastogenic cytokine interferon\u2010\u03b1 (IFN\u03b1), whose transcriptome is present in SLE monocytes, may be responsible. This study was undertaken to examine the effects of IFN\u03b1 and lupus on osteoclasts and erosion in the (NZB \u00d7 NZW)F<jats:sub>1<\/jats:sub> mouse model of SLE with K\/BxN serum\u2013induced arthritis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Systemic IFN\u03b1 levels in (NZB \u00d7 NZW)F<jats:sub>1<\/jats:sub> mice were elevated by administration of AdIFN\u03b1. SLE disease was marked by anti\u2013double\u2010stranded DNA (anti\u2010dsDNA) antibody titer and proteinuria, and <jats:italic>Ifi202<\/jats:italic> and <jats:italic>Mx1<\/jats:italic> expression represented the IFN\u03b1 transcriptome. Microfocal computed tomography was used to evaluate bone erosions. Flow cytometry for CD11b and CD11c was used to evaluate the frequency of circulating osteoclast precursors (OCPs) and myeloid dendritic cells (DCs) in blood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Administration of AdIFN\u03b1 to (NZB \u00d7 NZW)F<jats:sub>1<\/jats:sub> mice induced osteopetrosis. (NZB \u00d7 NZW)F<jats:sub>1<\/jats:sub> mice without autoimmune disease were fully susceptible to focal erosions in the setting of serum\u2010induced arthritis. However, (NZB \u00d7 NZW)F<jats:sub>1<\/jats:sub> mice with high anti\u2010dsDNA antibody titers and the IFN\u03b1 transcriptome were protected against bone erosions. AdIFN\u03b1 pretreatment of NZW mice before K\/BxN serum administration also resulted in protection against bone erosion (r<jats:sup>2<\/jats:sup> = 0.4720, <jats:italic>P<\/jats:italic> &lt; 0.01), which was associated with a decrease in the frequency of circulating CD11b+CD11c\u2212 OCPs and a concomitant increase in the percentage of CD11b+CD11c+ cells (r<jats:sup>2<\/jats:sup> = 0.6330, <jats:italic>P<\/jats:italic> &lt; 0.05), which are phenotypic of myeloid DCs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These findings suggest that IFN\u03b1 in SLE shifts monocyte development toward myeloid DCs at the expense of osteoclastogenesis, thereby resulting in decreased bone erosion.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.27312","type":"journal-article","created":{"date-parts":[[2010,1,13]],"date-time":"2010-01-13T15:45:58Z","timestamp":1263397558000},"page":"1127-1137","source":"Crossref","is-referenced-by-count":33,"title":["Mediation of nonerosive arthritis in a mouse model of lupus by interferon\u2010\u03b1\u2013stimulated monocyte differentiation that is nonpermissive of osteoclastogenesis"],"prefix":"10.1002","volume":"62","author":[{"given":"Kofi A.","family":"Mensah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Mathian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianping","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher T.","family":"Ritchlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward M.","family":"Schwarz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,3,30]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01661"},{"key":"e_1_2_7_3_2","first-page":"1670","article-title":"How often is seropositive rheumatoid arthritis an erosive disease? A 17\u2010year followup study","volume":"20","author":"Kaarela K","year":"1993","journal-title":"J Rheumatol"},{"key":"e_1_2_7_4_2","first-page":"643","article-title":"Correlations between clinical facets of outcome in rheumatoid arthritis","volume":"11","author":"Kaarela K","year":"1993","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/46303"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200010)43:10<2143::AID-ANR1>3.0.CO;2-S"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200316069"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.10097"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01921090"},{"key":"e_1_2_7_10_2","first-page":"63","volume-title":"The clinical management of systemic lupus erythematosus","author":"Stevens M","year":"1983"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.40.2.124"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.37.2.121"},{"key":"e_1_2_7_13_2","first-page":"347","article-title":"Coexistence of human immunodeficiency virus infection and systemic lupus erythematosus","volume":"22","author":"Molina JF","year":"1995","journal-title":"J Rheumatol"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002281-200309000-00005"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(04)00108-6"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197907053010102"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.6176024"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780250407"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20021553"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0337679100"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-857X(05)70140-X"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20021996"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.5.2499"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/416744a"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(01)00196-0"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1346.031"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.080808"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.23128"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-0266(03)00011-1"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni772"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.194.3.321"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.8.2544"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.191.10.1777"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.20-1-61"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.21890"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.8.5283"},{"key":"e_1_2_7_37_2","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.1998.13.12.1822"},{"key":"e_1_2_7_38_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI28084"},{"key":"e_1_2_7_39_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.23954"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.27312","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.27312","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T14:49:38Z","timestamp":1700750978000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.27312"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3,30]]},"references-count":38,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,4]]}},"alternative-id":["10.1002\/art.27312"],"URL":"https:\/\/doi.org\/10.1002\/art.27312","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,3,30]]}}}