{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T15:54:06Z","timestamp":1791820446325,"version":"4.3.4"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2010,1,13]],"date-time":"2010-01-13T00:00:00Z","timestamp":1263340800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2010,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To study the efficacy and safety of B cell depletion with rituximab, a chimeric murine\/human anti\u2010CD20 monoclonal antibody, in patients with primary Sj\u00f6gren's syndrome (SS) in a double\u2010blind, randomized, placebo\u2010controlled trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with active primary SS, as determined by the revised American\u2013European Consensus Group criteria, and a rate of stimulated whole saliva secretion of \u22650.15 ml\/minute were treated with either rituximab (1,000 mg) or placebo infusions on days 1 and 15. Patients were assigned randomly to a treatment group in a ratio of 2:1 (rituximab:placebo). Followup was conducted at 5, 12, 24, 36, and 48 weeks. The primary end point was the stimulated whole saliva flow rate, while secondary end points included functional, laboratory, and subjective variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirty patients with primary SS (29 female) were randomly allocated to a treatment group. The mean \u00b1 SD age of the patients receiving rituximab was 43 \u00b1 11 years and the disease duration was 63 \u00b1 50 months, while patients in the placebo group were age 43 \u00b1 17 years and had a disease duration of 67 \u00b1 63 months. In the rituximab group, significant improvements, in terms of the mean change from baseline compared with that in the placebo group, were found for the primary end point of the stimulated whole saliva flow rate (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.038 versus placebo) and also for various laboratory parameters (B cell and rheumatoid factor [RF] levels), subjective parameters (Multidimensional Fatigue Inventory [MFI] scores and visual analog scale [VAS] scores for sicca symptoms), and extraglandular manifestations. Moreover, in comparison with baseline values, rituximab treatment significantly improved the stimulated whole saliva flow rate (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.004) and several other variables (e.g., B cell and RF levels, unstimulated whole saliva flow rate, lacrimal gland function on the lissamine green test, MFI scores, Short Form 36 health survey scores, and VAS scores for sicca symptoms). One patient in the rituximab group developed mild serum sickness\u2013like disease.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These results indicate that rituximab is an effective and safe treatment strategy for patients with primary SS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.27314","type":"journal-article","created":{"date-parts":[[2010,1,13]],"date-time":"2010-01-13T10:46:04Z","timestamp":1263379564000},"page":"960-968","source":"Crossref","is-referenced-by-count":436,"title":["Effectiveness of rituximab treatment in primary Sj\u00f6gren's syndrome: A randomized, double\u2010blind, placebo\u2010controlled trial"],"prefix":"10.1002","volume":"62","author":[{"given":"J. M.","family":"Meijer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. 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M.","family":"Kallenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Bootsma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,3,30]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kep141"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.22536"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.21260"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.61.6.554"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kel266"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1972.sp009721"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(73)90089-7"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0722.2005.00241.x"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.61.2.137"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.60.12.1110"},{"key":"e_1_2_7_12_2","first-page":"924","article-title":"Oral and ocular manifestations in Sj\u00f6gren's syndrome","volume":"29","author":"Kalk WW","year":"2002","journal-title":"J Rheumatol"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3999(94)00125-O"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199206000-00002"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.22025"},{"key":"e_1_2_7_16_2","first-page":"20","article-title":"Improved health\u2010related quality of life for patients with active rheumatoid arthritis receiving rituximab: results of the dose\u2010ranging assessment","volume":"35","author":"Mease PJ","year":"2008","journal-title":"J Rheumatol"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kel393"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.029694"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.083865"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.38.938"},{"key":"e_1_2_7_21_2","first-page":"149","article-title":"Prednisone and piroxicam for treatment of primary Sj\u00f6gren's syndrome","volume":"11","author":"Fox PC","year":"1993","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.052647"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2008.01.001"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2008.10.004"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.23059"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-007-8005-6"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.092601"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.27314","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.27314","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T09:49:47Z","timestamp":1700732987000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.27314"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3,30]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,4]]}},"alternative-id":["10.1002\/art.27314"],"URL":"https:\/\/doi.org\/10.1002\/art.27314","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.3028958.3124055","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.3028958.2706058","asserted-by":"object"}]},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,3,30]]}}}