{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T19:51:21Z","timestamp":1791143481844,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2010,5,23]],"date-time":"2010-05-23T00:00:00Z","timestamp":1274572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2010,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To report the long\u2010term mortality in patients with Beh\u00e7et's disease (BD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cohort of 817 patients fulfilling the international criteria for BD from a single center in France were analyzed for causes of death, the standardized mortality ratio (SMR), and the factors associated with mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 817 patients with BD, 41 (5%) died after a median followup of 7.7 years, of whom 95.1% were male. The mean \u00b1 SD age at death was 34.8 \u00b1 11.9 years. Main causes of death included major vessel disease (mainly, arterial aneurysm and Budd\u2010Chiari syndrome) (43.9%), cancer and malignant hemopathy (14.6%), central nervous system involvement (12.2%), and sepsis (12.2%). The mortality rate at 1 year and 5 years was 1.2% and 3.3%, respectively. There was an increased mortality among patients ages 15\u201324 years (SMR 2.99, 95% confidence interval [95% CI] 1.54\u20135.39) and those ages 25\u201334 years (SMR 2.90, 95% CI 1.80\u20134.49) as compared with age\u2010and sex\u2010matched healthy controls. The mortality decreased in patients older than age 35 years (SMR 1.23, 95% CI 0.75\u20131.92). In multivariate analyses, male sex (hazard ratio [HR] 4.94, 95% CI 1.53\u201316.43), arterial involvement (HR 2.51, 95% CI 1.07\u20135.90), and a high number of BD flares (HR 2.37, 95% CI 1.09\u20135.14) were independently associated with the risk of mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The overall mortality in our BD cohort was 5% after a median followup of 7.7 years. Male sex, arterial involvement, and the number of flares were associated with mortality in BD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.27568","type":"journal-article","created":{"date-parts":[[2010,5,26]],"date-time":"2010-05-26T15:20:56Z","timestamp":1274887256000},"page":"2806-2812","source":"Crossref","is-referenced-by-count":271,"title":["Mortality in Beh\u00e7et's disease"],"prefix":"10.1002","volume":"62","author":[{"given":"D.","family":"Saadoun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Wechsler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Desseaux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. 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