{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:06:56Z","timestamp":1761512816394},"reference-count":12,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2010,5,24]],"date-time":"2010-05-24T00:00:00Z","timestamp":1274659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2010,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Anti\u2010SSA\/Ro antibodies are necessary but not sufficient to provoke autoimmune\u2010associated congenital heart block (CHB). Genetic factors are likely contributory. Accordingly, HLA\u2010related candidates and single\u2010nucleotide polymorphisms in the promoter region of tumor necrosis factor \u03b1 and codon 10 in transforming growth factor \u03b21 (TGF\u03b21) were evaluated in a unique family: the surrogate mother (anti\u2010SSA\/Ro positive), the biologic father, and the CHB\u2010affected child (product of ovodonation). There was an HLA mismatch between the affected child and the surrogate mother. However, both the biologic and the surrogate mothers shared DQ2 and the profibrosing leucine polymorphism at codon 10 of TGF\u03b2. In conclusion, we observed that CHB can develop in a genetically unrelated child exposed in utero to anti\u2010SSA\/Ro antibodies. Testing for anti\u2010SSA\/Ro antibodies might be considered in women undergoing artificial fertilization. It is possible that there is no direct association of maternal genes beyond a contributory role in generating the autoantibody.<\/jats:p>","DOI":"10.1002\/art.27575","type":"journal-article","created":{"date-parts":[[2010,5,27]],"date-time":"2010-05-27T01:03:08Z","timestamp":1274922188000},"page":"3119-3121","source":"Crossref","is-referenced-by-count":8,"title":["Passively acquired anti\u2010SSA\/Ro antibodies are required for congenital heart block following ovodonation but maternal genes are not"],"prefix":"10.1002","volume":"62","author":[{"given":"Antonio","family":"Brucato","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V\u00e9ronique","family":"Ramoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvana","family":"Penco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Sala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jill","family":"Buyon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Clancy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,5,24]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200108)44:8<1832::AID-ART320>3.0.CO;2-C"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1080\/0891693031000067340"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780290207"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.11103"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.6.3253"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1191\/096120399678847407"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1191\/096120399678847399"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199908)42:8<1757::AID-ANR27>3.0.CO;2-Z"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.4.2156"},{"key":"e_1_2_5_11_2","first-page":"S410","article-title":"HLA\u2010DRB1 relationships in neonatal lupus (NL) families","volume":"48","author":"Clancy R","year":"2003","journal-title":"Arthritis Rheum"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.21546"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh489"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.27575","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.27575","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T01:16:49Z","timestamp":1698715009000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.27575"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5,24]]},"references-count":12,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2010,10]]}},"alternative-id":["10.1002\/art.27575"],"URL":"https:\/\/doi.org\/10.1002\/art.27575","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,5,24]]}}}