{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T08:36:48Z","timestamp":1790671008602,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2010,7,28]],"date-time":"2010-07-28T00:00:00Z","timestamp":1280275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2010,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Churg\u2010Strauss syndrome (CSS) is a Th2\u2010mediated systemic vasculitis characterized by eosinophilic infiltration, blood eosinophilia, and high IgE levels. CCL17\/thymus and activation\u2013regulated chemokine (TARC) is a chemokine responsible for the recruitment of Th2 cells. This study was undertaken to explore a possible role of CCL17\/TARC in CSS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>CCL17\/TARC levels in serum from patients with active or inactive CSS, hypereosinophilic syndrome, systemic small\u2010vessel vasculitis other than CSS, other types of eosinophilia, and healthy controls were determined by enzyme\u2010linked immunosorbent assay. Biopsy samples of affected tissue from CSS patients were examined by immunohistochemical staining for Th2 infiltration and CCL17\/TARC expression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Serum CCL17\/TARC levels were significantly elevated in CSS patients with active disease (mean \u00b1 SEM 1,122.0 \u00b1 422.7 pg\/ml) compared with controls (220.6 \u00b1 27.9 pg\/ml) and patients with inactive disease (388.9 \u00b1 72.6 pg\/ml) (<jats:italic>P<\/jats:italic> &lt; 0.001 and <jats:italic>P<\/jats:italic> &lt; 0.05, respectively). These levels correlated with the clinical disease course of CSS and with absolute eosinophil counts as well as IgE levels. Infiltrating Th2 cells in active CSS lesions were evidenced by CD294 staining. CCL17\/TARC in the affected tissue of CSS patients was readily identified by immunohistochemical analysis. Elevated CCL17\/TARC levels were also noted in patients with hypereosinophilic syndrome (794.5 \u00b1 294.8 pg\/ml) and other disorders associated with eosinophilia (1,096.0 \u00b1 345.3 pg\/ml) (both <jats:italic>P<\/jats:italic> &lt; 0.005 versus controls).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CCL17\/TARC may contribute to CSS pathogenesis by recruitment of Th2 cells into affected tissue. Serum CCL17\/TARC levels reflect disease activity, and further studies to validate its use as an activity marker in CSS are warranted.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.27678","type":"journal-article","created":{"date-parts":[[2010,7,29]],"date-time":"2010-07-29T01:22:58Z","timestamp":1280366578000},"page":"3496-3503","source":"Crossref","is-referenced-by-count":80,"title":["CCL17\/thymus and activation\u2013related chemokine in Churg\u2010Strauss syndrome"],"prefix":"10.1002","volume":"62","author":[{"given":"Tom\u00e1\u0161","family":"Dallos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gisela Ruiz","family":"Heiland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Strehl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Karonitsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang L.","family":"Gross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Moosig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constanze","family":"Holl\u2010Ulrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg H. 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