{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:15:36Z","timestamp":1790194536553,"version":"4.1.0"},"reference-count":52,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2010,10,29]],"date-time":"2010-10-29T00:00:00Z","timestamp":1288310400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2010,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To test for associations between non\u2013major histocompatibility complex susceptibility loci previously reported in autoimmune diseases and juvenile idiopathic arthritis (JIA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Published autoimmune disease genome\u2010wide association studies were reviewed, and 519 single\u2010nucleotide polymorphisms (SNPs) were selected for association testing. The initial cohort included 809 JIA cases and 3,535 controls of non\u2010Hispanic, European ancestry. Of the SNPs, 257 were successfully genotyped, while 168 were imputed with quality. Based on findings in the initial cohort, replication was sought for 21 SNPs in a second cohort of 1,015 JIA cases and 1,569 controls collected in the US and Germany. For the initial cohort, tests for association were adjusted for potential confounding effects of population structure by including principal components derived from a genome\u2010wide association study as covariates in logistic regression models. Odds ratios (ORs) and 95% confidence intervals were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Testing for association of previously reported autoimmune disease genetic associations in the initial cohort suggested associations with JIA in 13 distinct loci. Of these, 7 were validated in the replication cohort. Meta\u2010analysis results for the replicating loci included PTPN22 (rs6679677 [OR 1.58, <jats:italic>P<\/jats:italic> = 1.98 \u00d7 10<jats:sup>\u221212<\/jats:sup>], rs2476601 [OR 1.64, <jats:italic>P<\/jats:italic> = 1.90 \u00d7 10<jats:sup>\u221213<\/jats:sup>], and rs2488457 [OR 1.32, <jats:italic>P<\/jats:italic> = 6.74 \u00d7 10<jats:sup>\u22128<\/jats:sup>]), PTPN2 (rs1893217 [OR = 1.33, <jats:italic>P<\/jats:italic> = 1.60 \u00d7 10<jats:sup>\u22129<\/jats:sup>] and rs7234029 [OR 1.35, <jats:italic>P<\/jats:italic> = 1.86 \u00d7 10<jats:sup>\u221210<\/jats:sup>]), ADAD1\u2010IL2\u2010IL21 (rs17388568 [OR 1.24, <jats:italic>P<\/jats:italic> = 1.13 \u00d7 10<jats:sup>\u22126<\/jats:sup>] and rs13143866 [OR 0.83, <jats:italic>P<\/jats:italic> = 1.95 \u00d7 10<jats:sup>\u22124<\/jats:sup>]), STAT4 (rs3821236 [OR = 1.27, <jats:italic>P<\/jats:italic> = 2.36 \u00d7 10<jats:sup>\u22126<\/jats:sup>] and rs7574865 [OR = 1.31, <jats:italic>P<\/jats:italic> = 2.21 \u00d7 10<jats:sup>\u22126<\/jats:sup>]), C12orf30 (rs17696736 [OR = 1.19, <jats:italic>P<\/jats:italic> = 2.59 \u00d7 10<jats:sup>\u22125<\/jats:sup>]), COG6 (rs7993214 [OR = 0.76, <jats:italic>P<\/jats:italic> = 1.10 \u00d7 10<jats:sup>\u22125<\/jats:sup>]), and ANGPT1 (rs1010824 [OR = 0.79, <jats:italic>P<\/jats:italic> = 2.91 \u00d7 10<jats:sup>\u22124<\/jats:sup>]). These polymorphisms have been reported in diseases such as rheumatoid arthritis, type 1 diabetes mellitus, Crohn's disease, and multiple sclerosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>General susceptibility loci for autoimmunity are shared across diseases, including JIA, suggesting the potential for common therapeutic targets and mechanisms.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.27688","type":"journal-article","created":{"date-parts":[[2010,8,19]],"date-time":"2010-08-19T03:17:43Z","timestamp":1282187863000},"page":"3265-3276","source":"Crossref","is-referenced-by-count":107,"title":["The susceptibility loci juvenile idiopathic arthritis shares with other autoimmune diseases extend to PTPN2, COG6, and ANGPT1"],"prefix":"10.1002","volume":"62","author":[{"given":"Susan D.","family":"Thompson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Sudman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula S.","family":"Ramos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miranda C.","family":"Marion","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Ryan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Tsoras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracey","family":"Weiler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Keddache","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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