{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T10:25:28Z","timestamp":1793701528600,"version":"4.5.1"},"reference-count":26,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2010,11,30]],"date-time":"2010-11-30T00:00:00Z","timestamp":1291075200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"DFG Focus Programme SPP 1468 \u201cOsteoimmunology-IMMUNOBONE: A program to unravel the mutual interactions between the immune system and bone\u201d"},{"name":"German Ministry for Education and Research ANCYLOSS project"},{"name":"Spondyloarthritis Immunology Research Alliance"},{"name":"European Union projects Masterswitch, Kinacept, and Adipoa"},{"name":"German Society of Rheumatology"},{"name":"Interdisciplinary Centre for Clinical Research at the University of Erlangen-Nuremberg"},{"name":"Articulum Fellowship"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the prevalence, clinical picture, and disease burden of arthritis in patients with hereditary hemochromatosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this cross\u2010sectional observational study of 199 patients with hemochromatosis and iron overload, demographic and disease\u2010specific variables, genotype, and organ involvement were recorded. The prevalence, intensity, and localization of joint pain were assessed, and a complete rheumatologic investigation was performed. Radiographs of the hands, knees, and ankles were scored for joint space narrowing, erosions, osteophytes, and chondrocalcinosis. In addition, the number and type of joint replacement surgeries were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Joint pain was reported by 72.4% of the patients. Their mean \u00b1 SD age at the time of the initial joint symptoms was 45.8 \u00b1 13.2 years. If joint pain was present, it preceded the diagnosis of hemochromatosis by a mean \u00b1 SD of 9.0 \u00b1 10.7 years. Bony enlargement was observed in 65.8% of the patients, whereas synovitis was less common (13.6%). Joint space narrowing and osteophytes as well as chondrocalcinosis of the wrist and knee joints were frequent radiographic features of hemochromatosis. Joint replacement surgery was common, with 32 patients (16.1%) undergoing total joint replacement surgery due to severe OA. The mean \u00b1 SD age of these patients was 58.3 \u00b1 10.4 years at time of joint replacement surgery. Female sex, metacarpophalangeal joint involvement, and the presence of chondrocalcinosis were associated with a higher risk of early joint failure (i.e., the need for joint replacement surgery).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Arthritis is a frequent, early, and severe symptom of hemochromatosis. Disease is not confined to involvement of the metacarpophalangeal joints and often leads to severe damage requiring the replacement of joints.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.27712","type":"journal-article","created":{"date-parts":[[2010,8,19]],"date-time":"2010-08-19T03:17:00Z","timestamp":1282187820000},"page":"3792-3798","source":"Crossref","is-referenced-by-count":87,"title":["Musculoskeletal disease burden of hereditary hemochromatosis"],"prefix":"10.1002","volume":"62","author":[{"given":"Enijad","family":"Sahinbegovic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom\u00e1\u0161","family":"Dallos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elmar","family":"Aigner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Axmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Manger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Englbrecht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian","family":"Sch\u00f6niger\u2010Hekele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Karonitsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanja","family":"Stamm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Farkas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Karger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"St\u00f6lzel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gernot","family":"Keysser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Datz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Schett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Zwerina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,11,30]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198511143132004"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-198305000-00002"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(97)80312-1"},{"key":"e_1_2_6_5_2","first-page":"539","article-title":"Hemochromatosis gene HFE Cys282Tyr mutation analysis in a cohort of Northeast German hospitalized patients supports assumption of a North to South allele frequency gradient throughout Germany","volume":"51","author":"Meier P","year":"2005","journal-title":"Clin Lab"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.beha.2004.08.023"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwg123"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(02)00018-1"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa073286"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-143-7-200510040-00010"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780070106"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.147.2.6300958"},{"key":"e_1_2_6_13_2","first-page":"321","article-title":"The natural history of arthritis in idiopathic haemochromatosis: progression of the clinical and radiological features over ten years","volume":"50","author":"Hamilton EB","year":"1981","journal-title":"Q J Med"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s003300050274"},{"key":"e_1_2_6_15_2","first-page":"376","article-title":"Hemochromatosis and femoral head aseptic osteonecrosis: a nonfortuitous association?","volume":"32","author":"Rollot F","year":"2005","journal-title":"J Rheumatol"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.31.2.98"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.24757"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.122119"},{"key":"e_1_2_6_19_2","first-page":"71","article-title":"Chondrocalcinosis and arthropathy: studies in haemochromatosis and in idiopathic chondrocalcinosis","volume":"39","author":"Atkins CJ","year":"1970","journal-title":"Q J Med"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00393-009-0590-8"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(99)00120-5"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780340314"},{"key":"e_1_2_6_23_2","first-page":"179","article-title":"Clinical and pathologic findings in hemochromatosis hip arthropathy","author":"Montgomery KD","year":"1998","journal-title":"Clin Orthop Relat Res"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2010.01.024"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2008.07.003"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002770100371"},{"key":"e_1_2_6_27_2","first-page":"153","article-title":"The hand arthropathy of hereditary hemochromatosis is strongly associated with iron overload","volume":"35","author":"Valenti L","year":"2008","journal-title":"J Rheumatol"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.27712","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.27712","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T13:41:53Z","timestamp":1696945313000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.27712"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11,30]]},"references-count":26,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["10.1002\/art.27712"],"URL":"https:\/\/doi.org\/10.1002\/art.27712","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,11,30]]}}}