{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T17:26:33Z","timestamp":1789406793138,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2010,11,30]],"date-time":"2010-11-30T00:00:00Z","timestamp":1291075200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001729","name":"Swedish Foundation for Strategic Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001729","id-type":"DOI","asserted-by":"crossref"}]},{"name":"NIH\/National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"name":"European Community Sixth Framework Programme (project Autocure)"},{"DOI":"10.13039\/501100004063","name":"Knut and Alice Wallenberg Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004063","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Alfred \u00d6sterlund Foundation"},{"DOI":"10.13039\/501100006075","name":"Greta and Johan Kock Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006075","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Inga-Britt and Arne Lundberg Foundation"},{"name":"King Gustav Vth's 80th Anniversary Foundation"},{"name":"University Hospital in Malm\u00f6\/Lund"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Cartilage oligomeric matrix protein (COMP) is a structural component of cartilage, where it catalyzes collagen fibrillogenesis. Elevated amounts of COMP are found in serum during increased turnover of cartilage associated with active joint disease, such as rheumatoid arthritis (RA) and osteoarthritis (OA). This study was undertaken to investigate the ability of COMP to regulate complement, a capacity that has previously been shown for some other cartilage proteins.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Regulation of complement by COMP was studied using functional in vitro assays. Inter\u2010actions between complement proteins and COMP were investigated by direct binding assay and electron microscopy. Circulating COMP and COMP\u2013C3b complexes in serum and synovial fluid from RA and OA patients and healthy controls were measured with a novel enzyme\u2010linked immunosorbent assay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We found in vivo evidence of complement activation by released COMP in the general circulation of patients with RA, but not patients with OA. COMP induced activation and deposition of C3b and C9 specifically via the alternative pathway of complement, which was attributable to direct interaction between COMP and properdin. Furthermore, COMP inhibited the classical and the lectin complement pathways due to direct interaction with the stalk region of C1q and mannose\u2010binding lectin, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>COMP is the first extracellular matrix protein for which an active role in inflammation has been demonstrated in vivo. It can activate one complement pathway at the same time as it has the potential to inhibit another. The net outcome of these interactions is most likely determined by the type of released COMP fragments, which may be disease specific.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.27720","type":"journal-article","created":{"date-parts":[[2010,8,29]],"date-time":"2010-08-29T14:15:30Z","timestamp":1283091330000},"page":"3574-3583","source":"Crossref","is-referenced-by-count":104,"title":["Regulation of complement by cartilage oligomeric matrix protein allows for a novel molecular diagnostic principle in rheumatoid arthritis"],"prefix":"10.1002","volume":"62","author":[{"given":"Kaisa 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