{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T04:02:14Z","timestamp":1769918534736,"version":"3.49.0"},"reference-count":47,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,1,28]],"date-time":"2011-01-28T00:00:00Z","timestamp":1296172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2011,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Assessment of infection with helminth parasites in murine models of disease could identify antiinflammatory mechanisms that translate into treatments for arthritic disease. The aim of this study was to test the ability of infection with the tapeworm <jats:italic>Hymenolepis diminuta<\/jats:italic> to ameliorate Freund's complete adjuvant (CFA)\u2013induced monoarthritis in mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Mice received CFA with or without <jats:italic>H diminuta<\/jats:italic>, and knee swelling, pain, and measures of inflammation were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Injection of CFA resulted in rapid (within 24 hours) and sustained (lasting 20 days) knee swelling, a decreased pain threshold, increased blood flow to the knee, and increased production of tumor necrosis factor \u03b1 and interleukin\u201012p40 (IL\u201012p40). In mice that were infected with <jats:italic>H diminuta<\/jats:italic> 8 days prior to receiving CFA, the severity of arthritis was reduced as assessed by these indices of inflammation and infection 2 days after CFA injection and resulted in more rapid resolution of knee swelling. This antiarthritic effect required a viable infection and was dependent on adaptive immunity, because infection with <jats:italic>H diminuta<\/jats:italic> did not protect mice lacking T cells and B cells or the IL\u20104 receptor \u03b1 chain from CFA\u2010induced inflammation. Interleukin\u201010 was of prime importance in the antiarthritic effect, because IL\u201010\u2013knockout mice were not protected by infection, the antiarthritic effect was ablated by use of neutralizing IL\u201010 antibodies, and transfer of CD4+ cells from infected wild\u2010type mice but not IL\u201010\u2013knockout mice significantly reduced CFA\u2010induced knee swelling.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In mice, the adaptive immune response to infection with <jats:italic>H diminuta<\/jats:italic> involves mobilization of IL\u201010, which has the concomitant advantage of dampening the innate immune responses that drive CFA\u2010induced joint inflammation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.30098","type":"journal-article","created":{"date-parts":[[2010,10,21]],"date-time":"2010-10-21T17:45:10Z","timestamp":1287683110000},"page":"434-444","source":"Crossref","is-referenced-by-count":45,"title":["Infection with an intestinal helminth parasite reduces Freund's complete adjuvant\u2013induced monoarthritis in mice"],"prefix":"10.1002","volume":"63","author":[{"given":"Meiqing","family":"Shi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arthur","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Prescott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher C. 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