{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T23:27:25Z","timestamp":1771457245389,"version":"3.50.1"},"reference-count":48,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2011,4,27]],"date-time":"2011-04-27T00:00:00Z","timestamp":1303862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2011,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the effectiveness of subsensory, pulsed electrical stimulation (PES) in the symptomatic management of osteoarthritis (OA) of the knee.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a double\u2010blind, randomized, placebo\u2010controlled, repeated\u2010measures trial in 70 participants with clinical and radiographically diagnosed OA of the knee who were randomized to either PES or placebo. The primary outcome was change in pain score over 26 weeks measured on a 100\u2010mm visual analog scale (VAS). Other measures included pain on the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), function on the WOMAC, patient's global assessment of disease activity (on a 100\u2010mm VAS), joint stiffness on the WOMAC, quality of life on the Medical Outcomes Study Short\u2010Form 36 (SF\u201036) health survey, physical activity (using the Human Activity Profile and an accelerometer), and global perceived effect (on an 11\u2010point scale).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010four participants were randomized to PES and 36 to placebo. Intent\u2010to\u2010treat analysis showed a statistically significant improvement in VAS pain score over 26 weeks in both groups, but no difference between groups (mean change difference 0.9 mm [95% confidence interval \u221211.7, 13.4]). Similarly, there were no differences between groups for changes in WOMAC pain, function, and stiffness scores (\u22125.6 [95% confidence interval \u221214.9, 3.6], \u22121.9 [95% confidence interval \u22129.7, 5.9], and 3.7 [95% confidence interval \u22126.0, 13.5], respectively), SF\u201036 physical and mental component summary scores (1.7 [95% confidence interval \u22121.5, 4.8] and 1.2 [95% confidence interval \u22122.9, 5.4], respectively), patient's global assessment of disease activity (\u22122.8 [95% confidence interval \u221213.9, 8.4]), or activity measures. Fifty\u2010six percent of the PES\u2010treated group achieved a clinically relevant 20\u2010mm improvement in VAS pain score at 26 weeks compared with 44% of controls (12% [95% confidence interval \u221211%, 33%]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this sample of subjects with mild\u2010to\u2010moderate symptoms and moderate\u2010to\u2010severe radiographic OA of the knee, 26 weeks of PES was no more effective than placebo.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.30258","type":"journal-article","created":{"date-parts":[[2011,2,10]],"date-time":"2011-02-10T23:08:24Z","timestamp":1297379304000},"page":"1333-1342","source":"Crossref","is-referenced-by-count":31,"title":["The effectiveness of pulsed electrical stimulation in the management of osteoarthritis of the knee: Results of a double\u2010blind, randomized, placebo\u2010controlled, repeated\u2010measures trial"],"prefix":"10.1002","volume":"63","author":[{"given":"Robyn E.","family":"Fary","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graeme J.","family":"Carroll","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom G.","family":"Briffa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. 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