{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T02:42:39Z","timestamp":1768272159471,"version":"3.49.0"},"reference-count":48,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":1554,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2011,6]]},"DOI":"10.1002\/art.30260","type":"journal-article","created":{"date-parts":[[2011,1,21]],"date-time":"2011-01-21T18:46:28Z","timestamp":1295635588000},"page":"1552-1561","source":"Crossref","is-referenced-by-count":9,"title":["Trans heterodimer between two non-arthritis-associated HLA alleles can predispose to arthritis in humanized mice"],"prefix":"10.1002","volume":"63","author":[{"given":"Marshall","family":"Behrens","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George K.","family":"Papadopoulos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonis","family":"Moustakas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Smart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harvinder","family":"Luthra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chella S.","family":"David","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veena","family":"Taneja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,5,31]]},"reference":[{"key":"10.1002\/art.30260-BIB1|cit1","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/BF00301502","article-title":"HLA-DR4-DQw8, but not DR4-DQw7 haplotypes occur in Indian patients with rheumatoid arthritis","volume":"11","author":"Taneja","year":"1992","journal-title":"Rheumatol Int"},{"key":"10.1002\/art.30260-BIB2|cit2","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1016\/S0140-6736(87)91548-0","article-title":"HLA-DQ \u03b2-chain polymorphism in HLA-DR4 haplotypes associated with rheumatoid arthritis","volume":"2","author":"Singal","year":"1987","journal-title":"Lancet"},{"key":"10.1002\/art.30260-BIB3|cit3","first-page":"16","article-title":"Protective and risk DR phenotypes in Asian Indian patients with rheumatoid arthritis","volume":"96","author":"Taneja","year":"1992","journal-title":"Indian J Med Res"},{"key":"10.1002\/art.30260-BIB4|cit4","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.2337\/db07-1331","article-title":"HLA DR-DQ haplotypes and genotypes and type 1 diabetes risk: analysis of the type 1 diabetes genetics consortium families","volume":"57","author":"Erlich","year":"2008","journal-title":"Diabetes"},{"key":"10.1002\/art.30260-BIB5|cit5","doi-asserted-by":"crossref","first-page":"COMMENT2002","DOI":"10.1186\/gb-2002-3-3-comment2002","article-title":"The gentle art of gene arrangement: the meaning of gene clusters","volume":"3","author":"Trowsdale","year":"2002","journal-title":"Genome Biol"},{"key":"10.1002\/art.30260-BIB6|cit6","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.1172\/JCI27620","article-title":"HLA-DQ2 and -DQ8 signatures of gluten T cell epitopes in celiac disease","volume":"116","author":"Tollefsen","year":"2006","journal-title":"J Clin Invest"},{"key":"10.1002\/art.30260-BIB7|cit7","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/sj.gene.6364106","article-title":"Genotype effects and epistasis in type 1 diabetes and HLA-DQ trans dimer associations with disease","volume":"5","author":"Koeleman","year":"2004","journal-title":"Genes Immun"},{"key":"10.1002\/art.30260-BIB8|cit8","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.1172\/JCI119760","article-title":"HLA-DQB1 polymorphism determines incidence, onset, and severity of collagen-induced arthritis in transgenic mice: implications in human rheumatoid arthritis","volume":"100","author":"Bradley","year":"1997","journal-title":"J Clin Invest"},{"key":"10.1002\/art.30260-BIB9|cit9","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1084\/jem.183.1.27","article-title":"HLA-DQ8 transgenic mice are highly susceptible to collagen-induced arthritis: a novel model for human polyarthritis","volume":"183","author":"Nabozny","year":"1996","journal-title":"J Exp Med"},{"key":"10.1002\/art.30260-BIB10|cit10","doi-asserted-by":"crossref","first-page":"5867","DOI":"10.4049\/jimmunol.168.11.5867","article-title":"CD4 and CD8 T cells in susceptibility\/protection to collagen-induced arthritis in HLA-DQ8-transgenic mice: implications for rheumatoid arthritis","volume":"168","author":"Taneja","year":"2002","journal-title":"J Immunol"},{"key":"10.1002\/art.30260-BIB11|cit11","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.4049\/jimmunol.174.2.1118","article-title":"Requirement for CD28 may not be absolute for collagen-induced arthritis: study with HLA-DQ8 transgenic mice","volume":"174","author":"Taneja","year":"2005","journal-title":"J Immunol"},{"key":"10.1002\/art.30260-BIB12|cit12","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1084\/jem.154.3.688","article-title":"Type II collagen-induced arthritis in mice. I. Major histocompatibility complex (I region) linkage and antibody correlates","volume":"154","author":"Wooley","year":"1981","journal-title":"J Exp Med"},{"key":"10.1002\/art.30260-BIB13|cit13","doi-asserted-by":"crossref","first-page":"2761","DOI":"10.4049\/jimmunol.156.8.2761","article-title":"Characterization of the antigenic structure of human type II collagen","volume":"156","author":"Krco","year":"1996","journal-title":"J Immunol"},{"key":"10.1002\/art.30260-BIB14|cit14","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/0092-8674(91)90448-8","article-title":"Mice lacking MHC class II molecules","volume":"66","author":"Cosgrove","year":"1991","journal-title":"Cell"},{"key":"10.1002\/art.30260-BIB15|cit15","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1002\/art.1780240605","article-title":"Immunogenetic control of experimental type II collagen-induced arthritis. I. Susceptibility and resistance among inbred strains of rats","volume":"24","author":"Griffiths","year":"1981","journal-title":"Arthritis Rheum"},{"key":"10.1002\/art.30260-BIB16|cit16","doi-asserted-by":"crossref","first-page":"2758","DOI":"10.4049\/jimmunol.153.6.2758","article-title":"Collagen-induced arthritis and TCRs in SWR and B10.Q mice expressing an Ek \u03b1 transgene","volume":"153","author":"Griffiths","year":"1994","journal-title":"J Immunol"},{"key":"10.1002\/art.30260-BIB17|cit17","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1007\/s002510050564","article-title":"FVB\/N (H2q) mouse is resistant to arthritis induction and exhibits a genomic deletion of T-cell receptor V \u03b2 gene segments","volume":"49","author":"Osman","year":"1999","journal-title":"Immunogenetics"},{"key":"10.1002\/art.30260-BIB18|cit18","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1007\/s002510050550","article-title":"T-cell receptor v\u03b2 deletion and v\u03b1 polymorphism are responsible for the resistance of SWR mouse to arthritis induction","volume":"49","author":"Osman","year":"1999","journal-title":"Immunogenetics"},{"key":"10.1002\/art.30260-BIB19|cit19","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1007\/s001250051350","article-title":"Modelling of the MHC II allele I-Ag7 of NOD mouse: pH-dependent changes in specificity at pockets 9 and 6 explain several of the unique properties of this molecule","volume":"43","author":"Moustakas","year":"2000","journal-title":"Diabetologia"},{"key":"10.1002\/art.30260-BIB20|cit20","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0198-8859(01)00377-9","article-title":"Mutational analysis of critical residues determining antigen presentation and activation of HLA-DQ0602 restricted T-cell clones","volume":"63","author":"Reichstetter","year":"2002","journal-title":"Hum Immunol"},{"key":"10.1002\/art.30260-BIB21|cit21","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1073\/pnas.0308458100","article-title":"Crystal structure of HLA-DQ0602 that protects against type 1 diabetes and confers strong susceptibility to narcolepsy","volume":"101","author":"Siebold","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1002\/art.30260-BIB22|cit22","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/88694","article-title":"Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type 1 diabetes","volume":"2","author":"Lee","year":"2001","journal-title":"Nat Immunol"},{"key":"10.1002\/art.30260-BIB23|cit23","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S1074-7613(00)80536-1","article-title":"Crystal structure of I-Ak in complex with a dominant epitope of lysozyme","volume":"8","author":"Fremont","year":"1998","journal-title":"Immunity"},{"key":"10.1002\/art.30260-BIB24|cit24","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1007\/s00251-007-0224-8","article-title":"The spectrum of HLA-DQ and HLA-DR alleles, 2006: a listing correlating sequence and structure with function","volume":"59","author":"Bondinas","year":"2007","journal-title":"Immunogenetics"},{"key":"10.1002\/art.30260-BIB25|cit25","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1136\/ard.2003.009969","article-title":"HLA-DR-DQ haplotypes and genotypes in Finnish patients with rheumatoid arthritis","volume":"63","author":"Laivoranta-Nyman","year":"2004","journal-title":"Ann Rheum Dis"},{"key":"10.1002\/art.30260-BIB26|cit26","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0198-8859(95)00165-4","article-title":"Polymorphism of HLA-DRB, -DQA1, and -DQB1 in rheumatoid arthritis in Asian Indians: association with DRB1*0405 and DRB1*1001","volume":"46","author":"Taneja","year":"1996","journal-title":"Hum Immunol"},{"key":"10.1002\/art.30260-BIB27|cit27","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1093\/intimm\/9.6.905","article-title":"Use of eluted peptide sequence data to identify the binding characteristics of peptides to the insulin-dependent diabetes susceptibility allele HLA-DQ8 (DQ 3.2)","volume":"9","author":"Godkin","year":"1997","journal-title":"Int Immunol"},{"key":"10.1002\/art.30260-BIB28|cit28","doi-asserted-by":"crossref","first-page":"4175","DOI":"10.1073\/pnas.0306885101","article-title":"Structural basis for HLA-DQ2-mediated presentation of gluten epitopes in celiac disease","volume":"101","author":"Kim","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1002\/art.30260-BIB29|cit29","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.4049\/jimmunol.156.6.2171","article-title":"Allele-specific motifs characterize HLA-DQ interactions with a diabetes-associated peptide derived from glutamic acid decarboxylase","volume":"156","author":"Kwok","year":"1996","journal-title":"J Immunol"},{"key":"10.1002\/art.30260-BIB30|cit30","doi-asserted-by":"crossref","first-page":"2468","DOI":"10.4049\/jimmunol.155.5.2468","article-title":"HLA-DQ polymorphisms are highly selective for peptide binding interactions","volume":"155","author":"Kwok","year":"1995","journal-title":"J Immunol"},{"key":"10.1002\/art.30260-BIB31|cit31","doi-asserted-by":"crossref","first-page":"3268","DOI":"10.4049\/jimmunol.180.5.3268","article-title":"Large-scale characterization of natural ligands explains the unique gluten-binding properties of HLA-DQ2","volume":"180","author":"Stepniak","year":"2008","journal-title":"J Immunol"},{"key":"10.1002\/art.30260-BIB32|cit32","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1007\/s002510050309","article-title":"Unique peptide binding characteristics of the disease-associated DQ(\u03b11*0501, \u03b21*0201) vs the non-disease-associated DQ(\u03b11*0201, \u03b21*0202) molecule","volume":"46","author":"Van de Wal","year":"1997","journal-title":"Immunogenetics"},{"key":"10.1002\/art.30260-BIB33|cit33","doi-asserted-by":"crossref","first-page":"5878","DOI":"10.1021\/bi983048m","article-title":"A conformational change in the human major histocompatibility complex protein HLA-DR1 induced by peptide binding","volume":"38","author":"Zarutskie","year":"1999","journal-title":"Biochemistry"},{"key":"10.1002\/art.30260-BIB34|cit34","doi-asserted-by":"crossref","first-page":"3463","DOI":"10.4049\/jimmunol.162.6.3463","article-title":"Sodium dodecyl sulfate stability of HLA-DR1 complexes correlates with burial of hydrophobic residues in pocket 1","volume":"162","author":"Natarajan","year":"1999","journal-title":"J Immunol"},{"key":"10.1002\/art.30260-BIB35|cit35","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.4049\/jimmunol.176.3.1988","article-title":"Allelic variation in key peptide-binding pockets discriminates between closely related diabetes-protective and diabetes-susceptible HLA-DQB1*06 alleles","volume":"176","author":"Ettinger","year":"2006","journal-title":"J Immunol"},{"key":"10.1002\/art.30260-BIB36|cit36","doi-asserted-by":"crossref","first-page":"3232","DOI":"10.4049\/jimmunol.165.6.3232","article-title":"\u03b257-Asp plays an essential role in the unique SDS stability of HLA-DQA1*0102\/DQB1*0602 \u03b1\u03b2 protein dimer, the class II MHC allele associated with protection from insulin-dependent diabetes mellitus","volume":"165","author":"Ettinger","year":"2000","journal-title":"J Immunol"},{"key":"10.1002\/art.30260-BIB37|cit37","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1016\/S0198-8859(99)00120-2","article-title":"Substitution of aspartic acid at \u03b257 with alanine alters MHC class II peptide binding activity but not protein stability: HLA-DQ (\u03b11*0201, \u03b21*0302) and (\u03b11*0201, \u03b21*0303)","volume":"60","author":"Sato","year":"1999","journal-title":"Hum Immunol"},{"key":"10.1002\/art.30260-BIB38|cit38","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/368215a0","article-title":"Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide","volume":"368","author":"Stern","year":"1994","journal-title":"Nature"},{"key":"10.1002\/art.30260-BIB39|cit39","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1093\/intimm\/7.8.1255","article-title":"Affinity for class II MHC determines the extent to which soluble peptides tolerize autoreactive T cells in naive and primed adult mice: implications for autoimmunity","volume":"7","author":"Liu","year":"1995","journal-title":"Int Immunol"},{"key":"10.1002\/art.30260-BIB40|cit40","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/BF03401615","article-title":"Quantitative analysis of peptides from myelin basic protein binding to the MHC class II protein, I-Au, which confers susceptibility to experimental allergic encephalomyelitis","volume":"2","author":"Fugger","year":"1996","journal-title":"Mol Med"},{"key":"10.1002\/art.30260-BIB41|cit41","doi-asserted-by":"crossref","first-page":"7949","DOI":"10.4049\/jimmunol.0902493","article-title":"New design of MHC class II tetramers to accommodate fundamental principles of antigen presentation","volume":"183","author":"Landais","year":"2009","journal-title":"J Immunol"},{"key":"10.1002\/art.30260-BIB42|cit42","doi-asserted-by":"crossref","first-page":"5098","DOI":"10.4049\/jimmunol.169.9.5098","article-title":"The HLA molecules DQA1*0501\/B1*0201 and DQA1*0301\/B1*0302 share an extensive overlap in peptide binding specificity","volume":"169","author":"Sidney","year":"2002","journal-title":"J Immunol"},{"key":"10.1002\/art.30260-BIB43|cit43","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1038\/ni.1780","article-title":"Differences in the risk of celiac disease associated with HLA-DQ2.5 or HLA-DQ2.2 are related to sustained gluten antigen presentation","volume":"10","author":"Fallang","year":"2009","journal-title":"Nat Immunol"},{"key":"10.1002\/art.30260-BIB44|cit44","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1007\/BF00401756","article-title":"Polymorphic structural features of modelled HLA-DQ molecules segregate according to susceptibility or resistance to IDDM","volume":"38","author":"Routsias","year":"1995","journal-title":"Diabetologia"},{"key":"10.1002\/art.30260-BIB45|cit45","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.4049\/jimmunol.160.5.2365","article-title":"A peptide binding motif for HLA-DQA1*0102\/DQB1*0602, the class II MHC molecule associated with dominant protection in insulin-dependent diabetes mellitus","volume":"160","author":"Ettinger","year":"1998","journal-title":"J Immunol"},{"key":"10.1002\/art.30260-BIB46|cit46","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1034\/j.1399-0039.1999.530111.x","article-title":"Impaired binding of a DQ2 and DQ8-binding HSV VP16 peptide to a DQA1*0501\/DQB1*0302 trans class II heterodimer","volume":"53","author":"Reichstetter","year":"1999","journal-title":"Tissue Antigens"},{"key":"10.1002\/art.30260-BIB47|cit47","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.4049\/jimmunol.150.6.2263","article-title":"HLA-DQ allelic polymorphisms constrain patterns of class II heterodimer formation","volume":"150","author":"Kwok","year":"1993","journal-title":"J Immunol"},{"key":"10.1002\/art.30260-BIB48|cit48","doi-asserted-by":"crossref","first-page":"R134","DOI":"10.1186\/ar2023","article-title":"Mice expressing HLA-DQ6\u03b18\u03b2 transgenes develop polychondritis spontaneously","volume":"8","author":"Lamoureux","year":"2006","journal-title":"Arthritis Res Ther"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.30260","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1002\/art.30260\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,4]],"date-time":"2023-06-04T23:06:44Z","timestamp":1685920004000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.30260"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5,31]]},"references-count":48,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,6]]}},"URL":"https:\/\/doi.org\/10.1002\/art.30260","relation":{},"ISSN":["0004-3591"],"issn-type":[{"value":"0004-3591","type":"print"}],"subject":[],"published":{"date-parts":[[2011,5,31]]}}}