{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:29:48Z","timestamp":1792542588911,"version":"4.5.0"},"reference-count":35,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2011,8,31]],"date-time":"2011-08-31T00:00:00Z","timestamp":1314748800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Although diagnostic criteria for generalized ligamentous laxity (hypermobility) in children are widely used, their validity may be limited, due to the lack of robust descriptive epidemiologic data on this condition. The present study was undertaken to describe the point prevalence and pattern of hypermobility in 14\u2010year\u2010old children from a population\u2010based cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a cross\u2010sectional analysis using the Avon Longitudinal Study of Parents and Children, a large population\u2010based birth cohort. Hypermobility among children in the cohort (mean age 13.8 years) was measured using the Beighton scoring system. Objective measures of physical activity were ascertained by accelerometry. Data on other variables, including puberty and socioeconomic status, were collected. Simple prevalence rates were calculated. Chi\u2010square tests and logistic regression analyses were used to assess associations of specific variables with hypermobility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 6,022 children evaluated, the prevalence of hypermobility (defined as a Beighton score of \u22654 [i.e., \u22654 joints affected]) in girls and boys age 13.8 years was 27.5% and 10.6%, respectively. Forty\u2010five percent of girls and 29% of boys had hypermobile fingers. There was a suggestion of a positive association between hypermobility in girls and variables including physical activity, body mass index, and maternal education. No associations were seen in boys.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We have shown that the prevalence of hypermobility in UK children is high, possibly suggesting that the Beighton score cutoff of \u22654 is too low or that this scoring is not appropriate for use in subjects whose musculoskeletal system is still developing. These results provide a platform to evaluate the relationships between the Beighton criteria and key clinical features (including pain), thereby testing the clinical validity of this scoring system in the pediatric population.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.30435","type":"journal-article","created":{"date-parts":[[2011,5,5]],"date-time":"2011-05-05T15:54:59Z","timestamp":1304610899000},"page":"2819-2827","source":"Crossref","is-referenced-by-count":139,"title":["Epidemiology of generalized joint laxity (hypermobility) in fourteen\u2010year\u2010old children from the UK: A population\u2010based evaluation"],"prefix":"10.1002","volume":"63","author":[{"given":"Jacqui","family":"Clinch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Deere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Sayers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shea","family":"Palmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Riddoch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan H.","family":"Tobias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma M.","family":"Clark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,8,31]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh639"},{"key":"e_1_2_7_3_2","first-page":"1003","article-title":"Hypermobility among Egyptian children: prevalence and features","volume":"25","author":"El\u2010Garf AK","year":"1998","journal-title":"J Rheumatol"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/38.10.1014"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2008.150839"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/PL00008391"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1590\/S1516-31802005000300006"},{"key":"e_1_2_7_8_2","first-page":"771","article-title":"Joint hypermobility in South Indian children","volume":"33","author":"Subramanyan V","year":"1996","journal-title":"Indian Pediatr"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-003-0434-9"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1080\/14038190601103621"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/01241398-199111000-00010"},{"key":"e_1_2_7_12_2","first-page":"916","article-title":"Articular hypermobility in school children in Sao Paulo, Brazil","volume":"20","author":"Forleo LH","year":"1993","journal-title":"J Rheumatol"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(85)80178-5"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.32.5.413"},{"key":"e_1_2_7_15_2","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1302\/0301-620X.46B1.40","article-title":"Persistent joint laxity and congenital dislocation of the hip","volume":"46","author":"Carter CO","year":"1964","journal-title":"J Bone Joint Surg Br"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2004.tb02749.x"},{"key":"e_1_2_7_17_2","first-page":"ii263","article-title":"Joint hypermobility syndrome is highly prevalent in general rheumatology clinics, its occurrence and clinical presentation being gender, age and race\u2010related","volume":"65","author":"Grahame R","year":"2006","journal-title":"Ann Rheumatic Dis"},{"key":"e_1_2_7_18_2","first-page":"4449","article-title":"Generalised joint hypermobility and benign joint hypermobility syndrome. 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