{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T18:28:05Z","timestamp":1780079285848,"version":"3.54.0"},"reference-count":20,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2011,10,28]],"date-time":"2011-10-28T00:00:00Z","timestamp":1319760000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Eosinophilia\u2013myalgia syndrome (EMS) is characterized by subacute onset of myalgias and peripheral eosinophilia, followed by chronic neuropathy and skin induration. An epidemic of EMS in 1989 was linked to consumption of L\u2010tryptophan that had originated from a single source. Following the ban by the Food and Drug Administration (FDA) on the sale of L\u2010tryptophan, the incidence of EMS declined rapidly. Moreover, no new cases have been described since the FDA ban was lifted in 2005. We report the clinical, histopathologic, and immunogenetic features of a new case of L\u2010tryptophan\u2013associated EMS, along with evidence of activated transforming growth factor \u03b2 and interleukin\u20104 signaling in the lesional skin.<\/jats:p>","DOI":"10.1002\/art.30514","type":"journal-article","created":{"date-parts":[[2011,6,23]],"date-time":"2011-06-23T20:00:48Z","timestamp":1308859248000},"page":"3633-3639","source":"Crossref","is-referenced-by-count":70,"title":["Post\u2010epidemic eosinophilia\u2013myalgia syndrome associated with L\u2010tryptophan"],"prefix":"10.1002","volume":"63","author":[{"given":"Jeffrey A.","family":"Allen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Peterson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Sufit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique E.","family":"Hinchcliff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Matthew","family":"Mahoney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tammara A.","family":"Wood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick W.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael L.","family":"Whitfield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Varga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,10,28]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199003293221301"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199003293221302"},{"key":"e_1_2_6_4_2","first-page":"1711","article-title":"Eosinophilia\u2010myalgia syndrome: mortality data from the US national surveillance system","volume":"20","author":"Swygert LA","year":"1993","journal-title":"J Rheumatol"},{"key":"e_1_2_6_5_2","first-page":"785","article-title":"Eosinophilia\u2010myalgia syndrome and L\u2010tryptophan\u2010containing products: New Mexico, Minnesota, Oregon, and New York, 1989","volume":"38","author":"Centers for Disease Control (CDC)","year":"1989","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199008093230601"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2270484"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00230724"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(12)61142-2"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116300"},{"key":"e_1_2_6_11_2","first-page":"1784","article-title":"Eosinophilia\u2010myalgia syndrome among the non\u2010L\u2010tryptophan users and pre\u2010epidemic cases","volume":"23","author":"Sullivan EA","year":"1996","journal-title":"J Rheumatol"},{"key":"e_1_2_6_12_2","first-page":"273","article-title":"Eosinophilia\u2010myalgia syndrome in patients ingesting a single source of L\u2010tryptophan","volume":"20","author":"Henning KJ","year":"1993","journal-title":"J Rheumatol"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.24460"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004356-198406000-00005"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4274(98)00223-9"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002696"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.318"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-113-2-124"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.161.19.2301"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-116-2-140"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12514683"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.30514","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.30514","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T17:56:51Z","timestamp":1697047011000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.30514"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10,28]]},"references-count":20,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2011,11]]}},"alternative-id":["10.1002\/art.30514"],"URL":"https:\/\/doi.org\/10.1002\/art.30514","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,10,28]]}}}