{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T16:07:09Z","timestamp":1767974829680,"version":"3.49.0"},"reference-count":49,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2011,10,28]],"date-time":"2011-10-28T00:00:00Z","timestamp":1319760000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The pathogenesis of psoriatic arthritis (PsA) remains poorly understood. The underlying chronic inflammatory immune response is thought to be triggered by unknown environmental factors potentially arising from a defective immune function. We undertook this study to determine whether an impaired acute inflammatory response by dendritic cells (DCs) might compromise the clearance of bacteria and predispose to chronic inflammation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We determined cytokine production by DCs from healthy controls and from patients with rheumatoid arthritis, PsA, and psoriasis in response to <jats:italic>Mycobacterium tuberculosis, Mycobacterium avium paratuberculosis<\/jats:italic>, and a range of other bacteria and Toll\u2010like receptor (TLR) ligands. Phenotypic differences involved in cellular responses against (myco)bacteria were determined by quantitative polymerase chain reaction and flow cytometry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The secretion of proinflammatory cytokines by PsA DCs was impaired upon in vitro challenge with mycobacteria and TLR\u20102 ligands. This impairment was associated with elevated serum levels of C\u2010reactive protein. The expression of TLR\u20102 and other receptors known to mediate mycobacterial recognition was unaltered. In contrast, the intracellular TLR inhibitors suppressor of cytokine signaling 3 and A20 were more highly expressed in DCs from PsA patients. PsA DCs further demonstrated up\u2010regulated levels of ATG16L1, NADPH oxidase 2, and LL37, which are molecules implicated in the immune response against intracellular bacteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings indicate that DCs from PsA patients have a disordered immune response toward some species of (myco)bacteria. This might predispose to impaired immune responses to, and in turn impaired clearance of, these bacteria, setting the stage for the chronic inflammation of joints, entheses, skin, and the gut.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.30577","type":"journal-article","created":{"date-parts":[[2011,8,2]],"date-time":"2011-08-02T20:43:27Z","timestamp":1312317807000},"page":"3313-3322","source":"Crossref","is-referenced-by-count":32,"title":["Impaired dendritic cell proinflammatory cytokine production in psoriatic arthritis"],"prefix":"10.1002","volume":"63","author":[{"given":"Mark H.","family":"Wenink","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim C. M.","family":"Santegoets","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Butcher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lenny","family":"van Bon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Femke G. M.","family":"Lamers\u2010Karnebeek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wim B.","family":"van den Berg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piet L. C. M.","family":"van Riel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iain B.","family":"McInnes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy R. D. J.","family":"Radstake","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,10,28]]},"reference":[{"key":"e_1_2_8_2_2","first-page":"1434","article-title":"From skin to bone: translational perspectives on psoriatic disease","volume":"35","author":"Ritchlin CT","year":"2008","journal-title":"J Rheumatol"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-007-0072-4"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.09023.x"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0804595"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.3.1935"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.313"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002301"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.311"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1310"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2008.00701.x"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1110"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.02.002"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-9740.2006.04277.x"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-0298-6_4"},{"key":"e_1_2_8_16_2","first-page":"656","article-title":"Synovial inflammation in active rheumatoid arthritis and psoriatic arthritis facilitates trapping of a variety of oral bacterial DNAs","volume":"24","author":"Moen K","year":"2006","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_8_17_2","first-page":"719","article-title":"Possible involvement of group A streptococci in the pathogenesis of psoriatic arthritis","volume":"9","author":"Vasey FB","year":"1982","journal-title":"J Rheumatol"},{"key":"e_1_2_8_18_2","first-page":"621","article-title":"High levels of antipeptidoglycan antibodies in psoriatic and other seronegative arthritides","volume":"17","author":"Rahman MU","year":"1990","journal-title":"J Rheumatol"},{"key":"e_1_2_8_19_2","first-page":"461","article-title":"Anti\u2010enterobacteria antibodies in psoriatic arthritis","volume":"10","author":"Lapadula G","year":"1992","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12354979"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2003.007104"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310302"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.21972"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01218-07"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0802217"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2009.08.004"},{"key":"e_1_2_8_27_2","first-page":"177","article-title":"The genetics of psoriatic arthritis: lessons from genome\u2010wide association studies","volume":"10","author":"Bowes J","year":"2010","journal-title":"Discov Med"},{"key":"e_1_2_8_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncprheum0625"},{"key":"e_1_2_8_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.02.015"},{"key":"e_1_2_8_30_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20091233"},{"key":"e_1_2_8_31_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0903753"},{"key":"e_1_2_8_32_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe0910690"},{"key":"e_1_2_8_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2008.07.009"},{"key":"e_1_2_8_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2911(09)05502-7"},{"key":"e_1_2_8_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2006.06.004"},{"key":"e_1_2_8_36_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.417"},{"key":"e_1_2_8_37_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.11.7190"},{"key":"e_1_2_8_38_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2009.01285.x"},{"key":"e_1_2_8_39_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20090480"},{"key":"e_1_2_8_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature06116"},{"key":"e_1_2_8_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1954"},{"key":"e_1_2_8_42_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2009.01381.x"},{"key":"e_1_2_8_43_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0811045106"},{"key":"e_1_2_8_44_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.24632"},{"key":"e_1_2_8_45_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0900713"},{"key":"e_1_2_8_46_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0306206"},{"key":"e_1_2_8_47_2","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0b013e3282f88b5d"},{"key":"e_1_2_8_48_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200839115"},{"key":"e_1_2_8_49_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01680-07"},{"key":"e_1_2_8_50_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.1.532-545.2005"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.30577","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.30577","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T17:55:55Z","timestamp":1697046955000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.30577"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10,28]]},"references-count":49,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2011,11]]}},"alternative-id":["10.1002\/art.30577"],"URL":"https:\/\/doi.org\/10.1002\/art.30577","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,10,28]]}}}