{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T07:34:26Z","timestamp":1790062466252,"version":"4.0.1"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,1,27]],"date-time":"2012-01-27T00:00:00Z","timestamp":1327622400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To describe the association of osteophytes with concomitant cartilage damage, assessed using semiquantitative magnetic resonance imaging (MRI), and to describe the prevalence of atrophic and hypertrophic phenotypes of tibiofemoral knee osteoarthritis (OA) in a population\u2010based cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Participants of the Framingham Knee Osteoarthritis Study were examined with a 1.5T MRI system using triplanar intermediate\u2010weighted fat\u2010suppressed sequences. Cartilage and osteophytes were assessed using the Whole\u2010Organ Magnetic Resonance Imaging Score (WORMS). Overall prevalence of knees with severe cartilage damage and concomitant osteophyte status were described. Odds ratios for the likelihood of having severe cartilage damage according to osteophyte size were estimated using a logistic regression model. An additional analysis assessed knees according to phenotype in relation to radiographic OA status, with the atrophic phenotype being defined as knees with absent or only tiny osteophytes (WORMS grade \u22642 on a 0\u20137 scale) in all 10 tibiofemoral subregions but exhibiting severe cartilage damage, and the hypertrophic phenotype being defined as knees with large osteophytes (WORMS grade \u22655 on a 0\u20137 scale) but lacking substantial cartilage damage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In this study, 1,597 knees of 1,248 subjects were included. Of the 67 knees with large osteophytes, 54 (80.6%) exhibited severe cartilage damage. The risk of severe cartilage damage increased markedly with increasing osteophyte size. Twenty\u2010one knees (1.3%) showed an atrophic phenotype. Only 3 knees (0.2%) exhibited a hypertrophic phenotype.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The majority of knees with severe tibiofemoral cartilage damage exhibited moderate to large osteophytes. The larger the osteophyte, the more likely was the presence of severe cartilage damage. A minority of knees exhibited the atrophic phenotype, which also included knees without radiographic OA. The hypertrophic phenotype was extremely rare.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.33344","type":"journal-article","created":{"date-parts":[[2011,9,14]],"date-time":"2011-09-14T23:31:26Z","timestamp":1316043086000},"page":"429-437","source":"Crossref","is-referenced-by-count":56,"title":["Prevalence of magnetic resonance imaging\u2013defined atrophic and hypertrophic phenotypes of knee osteoarthritis in a population\u2010based cohort"],"prefix":"10.1002","volume":"64","author":[{"given":"Frank W.","family":"Roemer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Guermazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingbo","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Mohr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David T.","family":"Felson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,1,27]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.16.4.494"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780290816"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780300811"},{"key":"e_1_2_7_5_2","first-page":"3","article-title":"Atlas of individual radiographic features in osteoarthritis","volume":"3","author":"Altman RD","year":"1995","journal-title":"Osteoarthritis Cartilage"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.57.7.401"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.21296"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1053\/joca.1999.0256"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.22016"},{"key":"e_1_2_7_10_2","first-page":"S128","article-title":"Magnetic resonance imaging prevalence of different features of knee osteoarthritis in persons with normal knee X\u2010rays","volume":"56","author":"Guermazi A","year":"2007","journal-title":"Arthritis Rheum"},{"key":"e_1_2_7_11_2","first-page":"S83","article-title":"Prevalence of MRI\u2010detected joint pathology of the knee in a population\u2010based sample: Framingham Osteoarthritis Study","volume":"62","author":"Niu J","year":"2010","journal-title":"Arthritis Rheum"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-7435(75)90037-7"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/1047-2797(94)00096-C"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.22557"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-004-2312-6"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2003.11.003"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.174.3.2305068"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2006.11.006"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.11328"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.34.1.12"},{"key":"e_1_2_7_21_2","first-page":"1734","article-title":"Quantitative microfocal radiographic assessment of osteoarthritis of the knee from weight bearing tunnel and semiflexed standing views","volume":"21","author":"Buckland\u2010Wright JC","year":"1994","journal-title":"J Rheumatol"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2523082197"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780330612"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.176.2.1760359"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2010.07.025"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00256-003-0635-z"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00256-008-0491-y"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.066183"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00256-004-0828-0"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.10573"}],"container-title":["Arthritis &amp; 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