{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T10:34:50Z","timestamp":1775817290114,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,1,27]],"date-time":"2012-01-27T00:00:00Z","timestamp":1327622400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess cartilage glycosaminoglycan content and cartilage thickness in the metacarpophalangeal (MCP) joints of patients with early rheumatoid arthritis (RA) and healthy volunteers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>After review board approval and informed consent were obtained, 22 subjects were prospectively enrolled (9 patients with early RA [7 women and 2 men with a mean \u00b1 SD age of 49 \u00b1 13 years; range 25\u201368 years] and 13 healthy volunteers [10 women and 3 men with a mean \u00b1 SD age of 51 \u00b1 12 years; range 25\u201366 years). In a total of 44 MCP joints of the index and middle fingers, measurements of cartilage thickness and delayed gadolinium\u2010enhanced magnetic resonance imaging (MRI) of cartilage (dGEMRIC) index (T1 [msec]) were obtained using the variable flip\u2010angle method and a 3T MR scanner. MRIs were evaluated for bone edema, erosions, and synovitis (using the RA MRI Scoring criteria). Student's <jats:italic>t<\/jats:italic>\u2010test was used to test the significance of differences between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean \u00b1 SD dGEMRIC index was 497 \u00b1 86 msec in healthy volunteers and was significantly lower in the early RA group (421 \u00b1 76 msec) (<jats:italic>P<\/jats:italic> = 0.042). There was no joint space narrowing seen on standard radiographs. No significant difference was found between cartilage thickness in patients with early RA and that in controls (index finger mean \u00b1 SD 1.27 \u00b1 0.23 mm in RA patients versus 1.46 \u00b1 0.34 mm in controls [<jats:italic>P<\/jats:italic> = 0.16] and middle finger 1.26 \u00b1 0.23 mm in RA patients versus 0.97 \u00b1 0.47 mm in controls [<jats:italic>P<\/jats:italic> = 0.10]). No significant correlation was noted between cartilage thickness and dGEMRIC index (R = 0.36, <jats:italic>P<\/jats:italic> = 0.88 in RA patients; R = 0.156, <jats:italic>P<\/jats:italic> = 0.445 in controls).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings indicate that cartilage damage is present in the MCP joints of patients with early RA despite the absence of joint space narrowing on standard radiographs and MRI. Cartilage damage in RA can be imaged with dGEMRIC.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.33352","type":"journal-article","created":{"date-parts":[[2011,9,28]],"date-time":"2011-09-28T02:34:59Z","timestamp":1317177299000},"page":"394-399","source":"Crossref","is-referenced-by-count":40,"title":["Molecular imaging of cartilage damage of finger joints in early rheumatoid arthritis with delayed gadolinium\u2010enhanced magnetic resonance imaging"],"prefix":"10.1002","volume":"64","author":[{"given":"Falk","family":"Miese","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Buchbender","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Axel","family":"Scherer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans\u2010J\u00f6rg","family":"Wittsack","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christof","family":"Specker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald","family":"Antoch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benedikt","family":"Ostendorf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,1,27]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.138693"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.10100459"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2007.11.002"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.099382"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1991.tb05587.x"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/ar2507"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2003.019992"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.131896"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.127324"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.11101841"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1053\/joca.2002.0847"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2203001662"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100100102"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.3109\/02841851.2010.510482"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.27584"},{"key":"e_1_2_7_17_2","first-page":"1385","article-title":"OMERACT rheumatoid arthritis magnetic resonance imaging studies: core set of MRI acquisitions, joint pathology definitions, and the OMERACT RA\u2010MRI scoring system","volume":"30","author":"Ostergaard M","year":"2003","journal-title":"J Rheumatol"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780380107"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.091265"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.33352","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.33352","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T01:42:27Z","timestamp":1696988547000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.33352"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1,27]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["10.1002\/art.33352"],"URL":"https:\/\/doi.org\/10.1002\/art.33352","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,1,27]]}}}