{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T14:58:36Z","timestamp":1791212316684,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,2,28]],"date-time":"2012-02-28T00:00:00Z","timestamp":1330387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000015","name":"Canadian Cancer Society Research Institute","doi-asserted-by":"crossref","award":["Operating grant 700922"],"award-info":[{"award-number":["Operating grant 700922"]}],"id":[{"id":"10.13039\/501100000015","id-type":"DOI","asserted-by":"crossref"}]},{"name":"McGill Integrated Cancer Training Program doctoral award"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>T cell protein tyrosine phosphatase (TC\u2010PTP) is an important regulator of hematopoiesis and cytokine signaling. Recently, several genome\u2010wide association studies have identified single\u2010nucleotide polymorphisms (SNPs) in the locus of TC\u2010PTP that are associated with rheumatoid arthritis and juvenile idiopathic arthritis, among other autoimmune diseases. The aim of this study was to evaluate the effect of TC\u2010PTP deficiency on the bone and joint environment using a knockout mouse model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Radiographic and micro\u2013computed tomography analyses were performed on femurs of 3\u2010week\u2010old mice. In addition, the femorotibial joints were assessed by histology, flow cytometry, and cytokine detection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Deficiency of <jats:italic>TC\u2010PTP<\/jats:italic> resulted in decreased bone volume as well as an increase in osteoclast density within the mouse femurs. In addition, synovitis, characterized by infiltration of mixed inflammatory cell types and proinflammatory cytokines, developed in the knee joints of <jats:italic>TC\u2010PTP<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These findings demonstrate that loss of TC\u2010PTP expression results in synovitis with several hallmarks of inflammatory arthritis. The inflammatory environment observed in the knee joints of <jats:italic>TC\u2010PTP<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> mice differs from the systemic inflammation previously described in these mice and merits further research into the role of TC\u2010PTP in the synovium. Furthermore, the results support recently described associations between SNPs in the <jats:italic>TC\u2010PTP<\/jats:italic> locus and arthritis incidence.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.33399","type":"journal-article","created":{"date-parts":[[2011,10,3]],"date-time":"2011-10-03T15:00:16Z","timestamp":1317654016000},"page":"752-761","source":"Crossref","is-referenced-by-count":17,"title":["T cell protein tyrosine phosphatase deficiency results in spontaneous synovitis and subchondral bone resorption in mice"],"prefix":"10.1002","volume":"64","author":[{"given":"Karen M.","family":"Doody","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie","family":"Bussi\u00e8res\u2010Marmen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ailian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maril\u00e8ne","family":"Paquet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet E.","family":"Henderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel L.","family":"Tremblay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,2,28]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.2.499"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.186.5.683"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-08-044370"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-09-3153"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2008.00743.x"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1991.tb04978.x"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-003-0125-3"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature05911"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.30235"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.582"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.27688"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddh034"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(00)00433-6"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/ar2337"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01932-05"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.21553"},{"key":"e_1_2_7_18_2","first-page":"969","volume-title":"Principles of bone biology","author":"Singer F","year":"1996"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780330302"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.21171"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.121657"},{"key":"e_1_2_7_22_2","first-page":"2116","article-title":"Immunohistological characteristics of T cell infiltrates in different forms of childhood onset chronic arthritis","volume":"23","author":"Murray KJ","year":"1996","journal-title":"J Rheumatol"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ken263"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.27284"},{"key":"e_1_2_7_25_2","first-page":"419","article-title":"Relationship between serum RANTES levels and radiological progression in rheumatoid arthritis patients treated with methotrexate","volume":"17","author":"Boiardi L","year":"1999","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.21962"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/347669a0"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1186\/ar2110"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2010.03.003"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20080611"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1186\/ar2333"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1186\/ar2292"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0008868"}],"container-title":["Arthritis &amp; 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