{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T01:52:11Z","timestamp":1789177931414,"version":"build-2803163510"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,3,27]],"date-time":"2012-03-27T00:00:00Z","timestamp":1332806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To examine whether patients with rheumatoid arthritis (RA) demonstrate patterns of prosthetic wear or cellular responses to implant wear debris different from those demonstrated by patients without inflammatory joint disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010eight patients who had undergone a primary revision of a total elbow arthroplasty for aseptic loosening between 1996 and 2008 were identified. Twenty\u2010five of these patients had RA, and 13 did not have inflammatory arthritis. Clinical data, gross wear patterns of the removed prostheses, and histopathologic analyses of peri\u2010implant tissue were compared between the patients with RA and those without RA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Evaluation of the retrieved prostheses showed that conformational change of the humeral polyethylene bushing was associated with the generation of polyethylene and metal particles. The amount and type of wear debris in periprosthetic tissues were similar in patients with and those without RA. Patients with RA who were not receiving anti\u2013tumor necrosis factor (anti\u2010TNF) therapy exhibited a histologic pattern of interstitial and sheet\u2010like lymphocytic infiltrates associated with a high plasma cell composition, which was different from the predominantly perivascular infiltrates with few plasma cells seen in non\u2010RA patients (<jats:italic>P<\/jats:italic>= 0.04). Patients with RA who were receiving anti\u2010TNF therapy showed a mixed perivascular and interstitial pattern of infiltrates with variable cell composition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with RA exhibited a distinct cellular response to implant wear debris compared with patients without RA. This reaction was unrelated to differences in the type or amount of wear debris and was mitigated by anti\u2010TNF therapy. These results suggest an intrinsic alteration in immunoregulation in RA and have implications for potential immunologic treatment of osteolysis in these patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.33459","type":"journal-article","created":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T11:44:58Z","timestamp":1322739898000},"page":"1005-1014","source":"Crossref","is-referenced-by-count":11,"title":["Cellular response to prosthetic wear debris differs in patients with and without rheumatoid arthritis"],"prefix":"10.1002","volume":"64","author":[{"given":"Anant","family":"Vasudevan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward F.","family":"DiCarlo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Wright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark P.","family":"Figgie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven R.","family":"Goldring","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa A.","family":"Mandl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,3,27]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ocl.2004.06.015"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.8.1.29"},{"key":"e_1_2_7_4_2","first-page":"1066","article-title":"Prosthetic synovitis: clinical and histologic characteristics","volume":"12","author":"Kaufman RL","year":"1985","journal-title":"J Rheumatol"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.F.01286"},{"key":"e_1_2_7_6_2","first-page":"9","article-title":"In patients with rheumatoid arthritis the tissue reaction associated with loosened total knee replacements exhibits features of a rheumatoid synovium","volume":"1","author":"Goldring SR","year":"1988","journal-title":"J Orthop Rheumatol"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.820170510"},{"key":"e_1_2_7_8_2","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1097\/BLO.0b013e3181591c62","article-title":"PFC knee replacement: osteolytic failures from extreme polyethylene degradation","volume":"464","author":"Casey D","year":"2007","journal-title":"Clin Orthop Relat Res"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-010-1372-y"},{"key":"e_1_2_7_10_2","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1002\/jbm.a.32368","article-title":"In vitro reactivity to implant metals demonstrates a person\u2010dependent association with both T\u2010cell and B\u2010cell activation","volume":"92","author":"Hallab NJ","year":"2010","journal-title":"J Biomed Mater Res A"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.89B5.18903"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-010-1649-1"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.17.3.205"},{"key":"e_1_2_7_14_2","first-page":"281","article-title":"Autoantigens and immune pathways in rheumatoid arthritis","volume":"22","author":"Corrigall VM","year":"2002","journal-title":"Crit Rev Immunol"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.139550"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-0266(03)00093-7"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60008-8"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.33459","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.33459","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T04:31:55Z","timestamp":1713155515000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.33459"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3,27]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["10.1002\/art.33459"],"URL":"https:\/\/doi.org\/10.1002\/art.33459","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,27]]}}}