{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T03:41:08Z","timestamp":1789184468254,"version":"build-2803163510"},"reference-count":13,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,3,27]],"date-time":"2012-03-27T00:00:00Z","timestamp":1332806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Borderline pulmonary arterial hypertension (PAH), characterized by a marked exercise\u2010induced increase in pulmonary artery pressure (PAP) with normal resting values, may precede overt PAH in systemic sclerosis (SSc). We undertook the present study to investigate whether PAH treatment is safe in these patients and might attenuate hemodynamic progression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>SSc patients with borderline PAH underwent right heart catheterization at baseline, after a 12\u2010month observation period, and subsequently after 6 months of bosentan therapy. Changes in mean PAP at 50W during the observation period versus during therapy were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ten patients completed the study. Mean PAP at rest, at 50W, and during maximal exercise increased significantly during the observation period (mean \u00b1 SD increases of 2.5 \u00b1 3.0 mm Hg [<jats:italic>P<\/jats:italic> = 0.03], 4.0 \u00b1 2.9 mm Hg [<jats:italic>P<\/jats:italic> = 0.002], and 6.8 \u00b1 4.1 mm Hg [<jats:italic>P<\/jats:italic> = 0.0005], respectively) and tended to decrease during the treatment period (decreases of 2.5 \u00b1 3.9 mm Hg [<jats:italic>P<\/jats:italic> = 0.07], 1.5 \u00b1 4.5 mm Hg [<jats:italic>P<\/jats:italic> = 0.32], and 1.8 \u00b1 7.0 mm Hg [<jats:italic>P<\/jats:italic> = 0.43], respectively). The changes during the observation period versus the therapy period were significantly different (<jats:italic>P<\/jats:italic> = 0.03 at rest, <jats:italic>P<\/jats:italic> = 0.01 at 50W [primary end point], and <jats:italic>P<\/jats:italic> = 0.02 during maximal exercise). The changes in resting pulmonary vascular resistance were also significantly different during the observation period (increase of 8 \u00b1 25 dynes \u00b7 seconds \u00b7 cm<jats:sup>\u22125<\/jats:sup>) versus during the therapy period (decrease of 45 \u00b1 22 dynes \u00b7 seconds \u00b7 cm<jats:sup>\u22125<\/jats:sup>) (<jats:italic>P<\/jats:italic> &lt; 0.0005). Changes in resting pulmonary arterial wedge pressure were not significantly different between the observation period and the treatment period, despite the significant increase during the observation period (2.6 \u00b1 2.5 mm Hg [<jats:italic>P<\/jats:italic> = 0.01]). No relevant adverse effects were reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In SSc patients with borderline abnormal pulmonary hemodynamics, resting and exercise PAP may increase significantly within 1 year of observation. Bosentan might be safe and effective to attenuate these changes. Randomized controlled trials are warranted to confirm the exploratory findings of this hypothesis\u2010generating pilot study.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.33460","type":"journal-article","created":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T11:44:28Z","timestamp":1322739868000},"page":"1257-1262","source":"Crossref","is-referenced-by-count":66,"title":["Pulmonary arterial hypertension therapy may be safe and effective in patients with systemic sclerosis and borderline pulmonary artery pressure"],"prefix":"10.1002","volume":"64","author":[{"given":"Gabor","family":"Kovacs","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Maier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Aberer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Brodmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Winfried","family":"Graninger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xhylsime","family":"Kqiku","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Scheidl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natascha","family":"Tr\u00f6ster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Hesse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lewis","family":"Rubin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Horst","family":"Olschewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,3,27]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00145608"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp297"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.787101"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2010.203471"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200806-953OC"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200904-0563OC"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.49.3812"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-2099"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780230510"},{"key":"e_1_2_8_11_2","first-page":"202","article-title":"Scleroderma (systemic sclerosis): classification, subsets and pathogenesis","volume":"15","author":"LeRoy EC","year":"1988","journal-title":"J Rheumatol"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.2.194"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-3042"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.114264"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.33460","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.33460","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T21:50:23Z","timestamp":1696974623000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.33460"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3,27]]},"references-count":13,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["10.1002\/art.33460"],"URL":"https:\/\/doi.org\/10.1002\/art.33460","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,27]]}}}