{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T08:52:04Z","timestamp":1791103924291,"version":"4.1.0"},"reference-count":10,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,4,26]],"date-time":"2012-04-26T00:00:00Z","timestamp":1335398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To carry out the first large\u2010scale population study of the prevalence of HLA\u2013B27 in the US, which is needed for public health planning purposes because of recent improvements in medical therapy and diagnostic testing for ankylosing spondylitis (AS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The national prevalence of HLA\u2013B27 was determined as part of the 2009 US National Health and Nutrition Examination Survey (NHANES), a cross\u2010sectional survey monitoring the health and nutritional status of the US civilian, noninstitutionalized population. DNA polymerase chain reaction analysis was conducted in samples from 2,320 adults ages 20\u201369 years from this nationally representative sample.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The age\u2010adjusted US prevalence of B27 was 6.1% (95% confidence interval [95% CI] 4.6\u20138.2). By race\/ethnicity, the prevalence of B27 was 7.5% (95% CI 5.3\u201310.4) among non\u2010Hispanic whites and 3.5% (95% CI 2.5\u20134.8) among all other US races\/ethnicities combined. In Mexican Americans, the prevalence was 4.6% (95% CI 3.4\u20136.1). The prevalence of B27 could not be reliably estimated for other US racial\/ethnic groups because of the low number of B27\u2010positive individuals in those groups. For adults 50\u201369 years of age, the prevalence of B27 was 3.6% (95% CI 2.2\u20135.8), which suggested a decrease in B27 with age. These prevalence estimates took into account the NHANES survey design and are reviewed with respect to data from the medical literature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings provide the first US national prevalence estimates for HLA\u2013B27. A decline in the prevalence of HLA\u2013B27 with age is suggested by these data but must be confirmed by additional studies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.33503","type":"journal-article","created":{"date-parts":[[2011,12,3]],"date-time":"2011-12-03T15:57:49Z","timestamp":1322927869000},"page":"1407-1411","source":"Crossref","is-referenced-by-count":147,"title":["The prevalence of HLA\u2013B27 in the US: Data from the US National Health and Nutrition Examination Survey, 2009"],"prefix":"10.1002","volume":"64","author":[{"given":"John D.","family":"Reveille","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosemarie","family":"Hirsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles F.","family":"Dillon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret D.","family":"Carroll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael H.","family":"Weisman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,4,26]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-0298-6_12"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2006.11.003"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2009.01.003"},{"key":"e_1_2_7_5_2","unstructured":"National Center for Health Statistics.Centers for Disease Control and Prevention. National Health and Nutrition Examination Survey 2009\u20102010. URL:http:\/\/www.cdc.gov\/nchs\/nhanes\/nhanes2009\u20102010\/nhanes09_10.htm."},{"key":"e_1_2_7_6_2","unstructured":"National Center for Health Statistics.Centers for Disease Control and Prevention. Appendix B: joint policy on variance estimation and statistical reporting standards on NHANES III and CSFII reports: HNIS\/NCHS Analytic Working Group recommendations September 23 1993. In: Analytic and reporting guidelines: the Third National Health and Nutrition Examination Survey NHANES III (1988\u201094). URL:http:\/\/www.cdc.gov\/nchs\/data\/nhanes\/nhanes3\/nh3gui.pdf."},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-35099-8_4"},{"key":"e_1_2_7_8_2","volume-title":"Analysis of complex surveys","author":"Skinner CJ","year":"1989"},{"key":"e_1_2_7_9_2","first-page":"S80","article-title":"Mortality in ankylosing spondylitis","volume":"26","author":"Zochling J","year":"2008","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780351211"},{"key":"e_1_2_7_11_2","first-page":"S11","article-title":"Ankylosing spondylitis\u2014cardiac manifestations","volume":"20","author":"Lautermann D","year":"2002","journal-title":"Clin Exp Rheumatol"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.33503","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.33503","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T01:54:02Z","timestamp":1698717242000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.33503"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4,26]]},"references-count":10,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["10.1002\/art.33503"],"URL":"https:\/\/doi.org\/10.1002\/art.33503","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4,26]]}}}