{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:23:52Z","timestamp":1790835832529,"version":"4.1.0"},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,5,25]],"date-time":"2012-05-25T00:00:00Z","timestamp":1337904000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the presence of pulmonary abnormalities in rheumatoid arthritis (RA)\u2013related autoantibody\u2013positive subjects without inflammatory arthritis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Forty\u2010two subjects who did not have inflammatory arthritis but were positive for anti\u2013cyclic citrullinated peptide antibodies and\/or \u22652 rheumatoid factor isotypes (a profile that is 96% specific for RA), 15 autoantibody\u2010negative controls, and 12 patients with established seropositive early RA (&lt;1\u2010year duration) underwent spirometry and high\u2010resolution computed tomography (HRCT) lung imaging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The median age of autoantibody\u2010positive subjects was 54 years, 52% were female, and 38% were ever\u2010smokers; these characteristics were not significantly different from those of autoantibody\u2010negative control subjects. No autoantibody\u2010positive subject had inflammatory arthritis based on joint examination. HRCT revealed that 76% of autoantibody\u2010positive subjects had airways abnormalities including bronchial wall thickening, bronchiectasis, centrilobular opacities, and air trapping, compared with 33% of autoantibody\u2010negative controls (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.005). The prevalence and type of lung abnormalities among autoantibody\u2010positive subjects were similar to those among patients with early RA. In 2 autoantibody\u2010positive subjects with airways disease, inflammatory arthritis classifiable as articular RA developed \u223c13 months after the lung evaluation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Airways abnormalities that are consistent with inflammation are common in autoantibody\u2010positive subjects without inflammatory arthritis and are similar to airways abnormalities seen in patients with early RA. These findings suggest that the lung may be an early site of autoimmune\u2010related injury and potentially a site of generation of RA\u2010related autoimmunity. Further studies are needed to define the mechanistic role of lung inflammation in the development of RA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.34344","type":"journal-article","created":{"date-parts":[[2011,12,19]],"date-time":"2011-12-19T10:59:28Z","timestamp":1324292368000},"page":"1756-1761","source":"Crossref","is-referenced-by-count":241,"title":["Brief Report: Airways abnormalities and rheumatoid arthritis\u2013related autoantibodies in subjects without arthritis: Early injury or initiating site of autoimmunity?"],"prefix":"10.1002","volume":"64","author":[{"given":"M. Kristen","family":"Demoruelle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael H.","family":"Weisman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip L.","family":"Simonian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Lynch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter B.","family":"Sachs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel F.","family":"Pedraza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie R.","family":"Harrington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason R.","family":"Kolfenbach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher C.","family":"Striebich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quyen N.","family":"Pham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin D.","family":"Strickland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian D.","family":"Petersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark C.","family":"Parish","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lezlie A.","family":"Derber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill M.","family":"Norris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V. Michael","family":"Holers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin D.","family":"Deane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,5,25]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2010.02.001"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200703-045MS"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1080\/03009740701393957"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-009-1128-9"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.139527"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.24833"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310302"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2462070712"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-0174"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.21575"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI28756"},{"key":"e_1_2_6_13_2","first-page":"319","article-title":"Autoantibodies in serum and sputum from patients with cystic fibrosis","volume":"87","author":"Schiotz PO","year":"1979","journal-title":"Acta Pathol Microbiol Scand C"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.075192"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2009.00850.x"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1186\/ar2913"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2512081242"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.34344","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.34344","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T09:40:30Z","timestamp":1698745230000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.34344"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5,25]]},"references-count":16,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["10.1002\/art.34344"],"URL":"https:\/\/doi.org\/10.1002\/art.34344","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.716748323.792103381","asserted-by":"object"}]},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5,25]]}}}