{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T15:27:11Z","timestamp":1789918031510,"version":"4.0.1"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,5,25]],"date-time":"2012-05-25T00:00:00Z","timestamp":1337904000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess fetal and maternal outcomes in women with systemic sclerosis (SSc).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospectively collected data on 99 women with SSc from 25 Italian centers were analyzed retrospectively. Women with SSc were observed during 109 pregnancies (from 2000 to 2011), and outcomes were compared to those in the general obstetric population (total of 3,939 deliveries). The maternal age at conception was a mean \u00b1 SD 31.8 \u00b1 5.3 years, and the median disease duration at conception was 60 months (range 2\u2013193 months).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>SSc patients, compared to the general obstetric population, had a significantly increased frequency of preterm deliveries (25% versus 12%) and severe preterm deliveries (&lt;34 weeks of gestation) (10% versus 5%), intrauterine growth restriction (6% versus 1%), and babies with very\u2010low birth weight (5% versus 1%). Results of multivariable analysis showed that corticosteroid use was associated with preterm deliveries (odds ratio [OR] 3.63, 95% confidence interval [95% CI] 1.12\u201311.78), whereas the use of folic acid (OR 0.30, 95% CI 0.10\u20130.91) and presence of anti\u2013Scl\u201070 antibodies (OR 0.26, 95% CI 0.08\u20130.85) were protective. The disease remained stable in most SSc patients, but there were 4 cases of progression of disease within 1 year from delivery, all in anti\u2013Scl\u201070 antibody\u2013positive women, 3 of whom had a disease duration of &lt;3 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Women with SSc can have successful pregnancies, but they have a higher\u2010than\u2010normal risk of preterm delivery, intrauterine growth restriction, and babies with very\u2010low birth weight. Progression of the disease during or after pregnancy is rare, but possible. High\u2010risk multidisciplinary management should be standard for these patients, and pregnancy should be avoided in women with severe organ damage and postponed in women with SSc of recent onset, particularly if the patient is positive for anti\u2013Scl\u201070 antibodies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.34350","type":"journal-article","created":{"date-parts":[[2011,12,28]],"date-time":"2011-12-28T09:34:23Z","timestamp":1325064863000},"page":"1970-1977","source":"Crossref","is-referenced-by-count":98,"title":["Brief Report: Successful pregnancies but a higher risk of preterm births in patients with systemic sclerosis: An Italian multicenter 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