{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T07:41:51Z","timestamp":1780472511603,"version":"3.54.1"},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,7,27]],"date-time":"2012-07-27T00:00:00Z","timestamp":1343347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>In a genome\u2010wide association study of Caucasian patients with juvenile idiopathic arthritis (JIA), we have previously described findings limited to autoimmunity loci shared by JIA and other diseases. The present study was undertaken to identify novel JIA\u2010predisposing loci using genome\u2010wide approaches.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The discovery cohort consisted of Caucasian JIA cases (n = 814) and local controls (n = 658) genotyped on the Affymetrix Genome\u2010Wide SNP 6.0 Array, along with 2,400 out\u2010of\u2010study controls. In a replication study, we genotyped 10 single\u2010nucleotide polymorphisms (SNPs) in 1,744 cases and 7,010 controls from the US and Europe.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Analysis within the discovery cohort provided evidence of associations at 3q13 within <jats:italic>C3orf1<\/jats:italic> and near <jats:italic>CD80<\/jats:italic> (rs4688011) (odds ratio [OR] 1.37, <jats:italic>P<\/jats:italic> = 1.88 \u00d7 10<jats:sup>\u22126<\/jats:sup>) and at 10q21 near <jats:italic>JMJD1C<\/jats:italic> (rs647989 [OR 1.59, <jats:italic>P<\/jats:italic> = 6.1 \u00d7 10<jats:sup>\u22128<\/jats:sup>], rs12411988 [OR 1.57, <jats:italic>P<\/jats:italic> = 1.16 \u00d7 10<jats:sup>\u22127<\/jats:sup>], and rs10995450 [OR 1.31, <jats:italic>P<\/jats:italic> = 6.74 \u00d7 10<jats:sup>\u22125<\/jats:sup>]). Meta\u2010analysis provided further evidence of association for these 4 SNPs (<jats:italic>P<\/jats:italic> = 3.6 \u00d7 10<jats:sup>\u22127<\/jats:sup> for rs4688011, <jats:italic>P<\/jats:italic> = 4.33 \u00d7 10<jats:sup>\u22125<\/jats:sup> for rs6479891, <jats:italic>P<\/jats:italic> = 2.71 \u00d7 10<jats:sup>\u22125<\/jats:sup> for rs12411988, and <jats:italic>P<\/jats:italic> = 5.39 \u00d7 10<jats:sup>\u22125<\/jats:sup> for rs10995450). Gene expression data on 68 JIA cases and 23 local controls showed <jats:italic>cis<\/jats:italic> expression quantitative trait locus associations for <jats:italic>C3orf1<\/jats:italic> SNP rs4688011 (<jats:italic>P<\/jats:italic> = 0.024 or <jats:italic>P<\/jats:italic> = 0.034, depending on the probe set) and <jats:italic>JMJD1C<\/jats:italic> SNPs rs6479891 and rs12411988 (<jats:italic>P<\/jats:italic> = 0.01 or <jats:italic>P<\/jats:italic> = 0.04, depending on the probe set and <jats:italic>P<\/jats:italic> = 0.008, respectively). Using a variance component liability model, it was estimated that common SNP variation accounts for approximately one\u2010third of JIA susceptibility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Genetic association results and correlated gene expression findings provide evidence of JIA association at 3q13 and suggest novel genes as plausible candidates in disease pathology.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.34429","type":"journal-article","created":{"date-parts":[[2012,2,21]],"date-time":"2012-02-21T19:36:34Z","timestamp":1329852994000},"page":"2781-2791","source":"Crossref","is-referenced-by-count":64,"title":["Genome\u2010wide association analysis of juvenile idiopathic arthritis identifies a new susceptibility locus at chromosomal region 3q13"],"prefix":"10.1002","volume":"64","author":[{"given":"Susan D.","family":"Thompson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miranda 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