{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T17:21:01Z","timestamp":1791566461047,"version":"4.3.4"},"reference-count":15,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2012,10,27]],"date-time":"2012-10-27T00:00:00Z","timestamp":1351296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The complication of interstitial lung disease (ILD) in polymyositis\/dermatomyositis (PM\/DM) is associated with anti\u2013aminoacyl\u2013transfer RNA synthetase (anti\u2010aaRS) antibody or anti\u2013melanoma differentiation\u2013associated gene 5 (anti\u2013MDA\u20105) antibody positivity. Anti\u2013MDA\u20105 antibody is associated with clinically amyopathic DM and fatal outcome due to rapidly progressive ILD in Asian populations. The association between genetic factors and anti\u2013MDA\u20105 antibody\u2013positive DM is unclear. This study was undertaken to investigate the HLA\u2013DRB1 genotype in patients with anti\u2013MDA\u20105 antibody\u2013positive DM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We examined genetic differences among 17 patients with anti\u2013MDA\u20105 antibody\u2013positive DM, 33 patients with anti\u2010aaRS antibody\u2013positive PM\/DM, 33 patients with PM\/DM without anti\u2010aaRS antibody or ILD, and 265 healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The frequencies of HLA\u2013DRB1*0101 and DRB1*0405 were 29% and 71%, respectively, in patients with anti\u2013MDA\u20105 antibody\u2013positive DM, which were higher than the frequencies in healthy controls (10% and 25%, respectively). Among the 17 patients with anti\u2013MDA\u20105 antibody\u2013positive DM, 16 (94%) harbored either the DRB1*0101 or DRB1*0405 allele. The combined frequency of the DRB1*0101 allele and the DRB1*0405 allele was significantly higher in patients with anti\u2013MDA\u20105 antibody\u2013positive DM than in patients with PM\/DM without anti\u2010aaRS antibody or ILD, with an odds ratio (OR) of 42.7 (95% confidence interval [95% CI] 4.9\u2013370.2) (<jats:italic>P<\/jats:italic> = 1.1 \u00d7 10<jats:sup>\u22125<\/jats:sup>), or in patients with anti\u2010aaRS antibody\u2013positive PM\/DM (OR 13.3 [95% CI 1.6\u2013112.6], <jats:italic>P<\/jats:italic> = 4.5 \u00d7 10<jats:sup>\u22123<\/jats:sup>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings indicate that HLA\u2013DRB1*0101\/*0405 is associated with susceptibility to anti\u2013MDA\u20105 antibody\u2013positive DM in the Japanese population.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.34657","type":"journal-article","created":{"date-parts":[[2012,8,8]],"date-time":"2012-08-08T17:05:30Z","timestamp":1344445530000},"page":"3736-3740","source":"Crossref","is-referenced-by-count":96,"title":["Brief Report: Association of HLA\u2013DRB1*0101\/*0405 with susceptibility to anti\u2013melanoma differentiation\u2013associated gene 5 antibody\u2013positive dermatomyositis in the Japanese population"],"prefix":"10.1002","volume":"64","author":[{"given":"Takahisa","family":"Gono","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Kawaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masataka","family":"Kuwana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Sugiura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takefumi","family":"Furuya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kae","family":"Takagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisae","family":"Ichida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Katsumata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Hanaoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Ota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisashi","family":"Yamanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,10,27]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)05157-0"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.10.041"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.24621"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kep375"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keq149"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2008.01.002"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780330826"},{"key":"e_1_2_7_9_2","first-page":"1768","article-title":"Immunogenetic features in 120 Japanese patients with idiopathic inflammatory myopathy","volume":"31","author":"Furuya T","year":"2004","journal-title":"J Rheumatol"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197502132920706"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.120621"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.2.ats3-00"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02342437"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.78.3.223"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(92)90041-V"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2009.04.006"}],"container-title":["Arthritis &amp; 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