{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T03:37:43Z","timestamp":1789875463565,"version":"4.0.1"},"reference-count":32,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2012,11,28]],"date-time":"2012-11-28T00:00:00Z","timestamp":1354060800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To study the relationship between cherry intake and the risk of recurrent gout attacks among individuals with gout.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a case\u2013crossover study to examine the associations of a set of putative risk factors with recurrent gout attacks. Individuals with gout were prospectively recruited and followed up online for 1 year. Participants were asked to provide the following information regarding gout attacks: the onset date of the gout attack, symptoms and signs, medications (including antigout medications), and exposure to potential risk factors (including daily intake of cherries and cherry extract) during the 2\u2010day period prior to the gout attack. We assessed the same exposure information over 2\u2010day control periods. We estimated the risk of recurrent gout attacks related to cherry intake using conditional logistic regression. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Our study included 633 individuals with gout. Cherry intake over a 2\u2010day period was associated with a 35% lower risk of gout attacks compared with no intake (multivariate OR 0.65 [95% CI 0.50\u20130.85]). Cherry extract intake showed a similar inverse association (multivariate OR 0.55 [95% CI 0.30\u20130.98]). The effect of cherry intake persisted across subgroups stratified by sex, obesity status, purine intake, alcohol use, diuretic use, and use of antigout medications. When cherry intake was combined with allopurinol use, the risk of gout attacks was 75% lower than during periods without either exposure (OR 0.25 [95% CI 0.15\u20130.42]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings suggest that cherry intake is associated with a lower risk of gout attacks.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.34677","type":"journal-article","created":{"date-parts":[[2012,9,30]],"date-time":"2012-09-30T14:05:11Z","timestamp":1349013911000},"page":"4004-4011","source":"Crossref","is-referenced-by-count":150,"title":["Cherry consumption and decreased risk of recurrent gout attacks"],"prefix":"10.1002","volume":"64","author":[{"given":"Yuqing","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuhina","family":"Neogi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Chaisson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Hunter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyon K.","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,11,28]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.30520"},{"key":"e_1_2_6_3_2","first-page":"2403","article-title":"Epidemiology of gout: is the incidence rising?","volume":"29","author":"Arromdee E","year":"2002","journal-title":"J Rheumatol"},{"key":"e_1_2_6_4_2","first-page":"104","article-title":"Frequency and predictors of inappropriate management of recurrent gout attacks in a longitudinal study","volume":"33","author":"Neogi T","year":"2006","journal-title":"J Rheumatol"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780160402"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/133.6.1826"},{"key":"e_1_2_6_7_2","first-page":"53","article-title":"Inhibitory effects of tart cherry (Prunus cerasus) juice on xanthine oxidoreductase activity and its hypouricemic and antioxidant effects on rats","volume":"15","author":"Haidari F","year":"2009","journal-title":"Malays J Nutr"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1021\/np980268s"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1078\/0944-7113-00053"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2008.11.042"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/136.4.981"},{"issue":"3","key":"e_1_2_6_12_2","first-page":"iii610","article-title":"Effect of cherry juice concentration on the secretion of interleukins by human monocytes exposed to monosodium urate crystals in vitro","volume":"69","author":"Schlesinger N","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1080\/03009740600704155"},{"key":"e_1_2_6_14_2","unstructured":"US Food and Drug Administration. List of firms receiving warning letters regarding cherry and other fruit\u2010based products with disease claims in labeling. 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