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Twelve of the rats that received particles also received sclerostin antibody treatment. The 3 groups of rats were maintained for 12 weeks in a pathogen\u2010free environment, at which time mechanical, micro\u2013computed tomography, and dynamic and static histomorphometry end points were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sclerostin antibody treatment completely blocked the negative effect of the lipopolysaccharide\u2010doped polyethylene particles on implant fixation and peri\u2010implant bone volume by increasing the bone formation rate and depressing bone resorption.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Anabolic agents targeting the Wnt signaling pathway are a promising new alternative for the prevention of periprosthetic osteolysis and aseptic loosening.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.37697","type":"journal-article","created":{"date-parts":[[2012,11,28]],"date-time":"2012-11-28T20:20:57Z","timestamp":1354134057000},"page":"4012-4020","source":"Crossref","is-referenced-by-count":57,"title":["Sclerostin antibody prevents particle\u2010induced implant loosening by stimulating bone formation and inhibiting bone resorption in a rat model"],"prefix":"10.1002","volume":"64","author":[{"given":"Shuo","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amarjit S.","family":"Virdi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kotaro","family":"Sena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dale 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