{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T12:26:54Z","timestamp":1792844814620,"version":"4.5.0"},"reference-count":57,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,3,28]],"date-time":"2013-03-28T00:00:00Z","timestamp":1364428800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Familial aggregation of fibromyalgia has been increasingly recognized. The goal of this study was to conduct a genome\u2010wide linkage scan to identify susceptibility loci for fibromyalgia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We genotyped members of 116 families from the Fibromyalgia Family Study and performed a model\u2010free genome\u2010wide linkage analysis of fibromyalgia with 341 microsatellite markers, using the Haseman\u2010Elston regression approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The estimated sibling recurrence risk ratio (\u03bb\n                      <jats:sub>s<\/jats:sub>\n                      ) for fibromyalgia was 13.6 (95% confidence interval 10.0\u201318.5), based on a reported population prevalence of 2%. Genome\u2010wide suggestive evidence of linkage was observed at markers D17S2196 (empirical\n                      <jats:italic>P<\/jats:italic>\n                      [\n                      <jats:italic>P<\/jats:italic>\n                      <jats:sub>e<\/jats:sub>\n                      ] = 0.00030) and D17S1294 (\n                      <jats:italic>P<\/jats:italic>\n                      <jats:sub>e<\/jats:sub>\n                      = 0.00035) on chromosome 17p11.2\u2013q11.2.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The estimated sibling recurrence risk ratio (\u03bb\n                      <jats:sub>s<\/jats:sub>\n                      ) observed in this study suggests a strong genetic component of fibromyalgia. This is the first report of genome\u2010wide suggestive linkage of fibromyalgia to the chromosome 17p11.2\u2013q11.2 region. Further investigation of these multicase families from the Fibromyalgia Family Study is warranted to identify potential causal risk variants for fibromyalgia.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.37842","type":"journal-article","created":{"date-parts":[[2012,12,28]],"date-time":"2012-12-28T12:04:33Z","timestamp":1356696273000},"page":"1122-1128","source":"Crossref","is-referenced-by-count":122,"title":["The Fibromyalgia Family Study: A Genome\u2010Wide Linkage Scan Study"],"prefix":"10.1002","volume":"65","author":[{"given":"Lesley M.","family":"Arnold","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinbo","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. 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