{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T11:27:07Z","timestamp":1770895627960,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,8,26]],"date-time":"2013-08-26T00:00:00Z","timestamp":1377475200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NIH","award":["AI-050864"],"award-info":[{"award-number":["AI-050864"]}]},{"name":"NIH","award":["AR-051394"],"award-info":[{"award-number":["AR-051394"]}]},{"name":"NIH","award":["AI-61479"],"award-info":[{"award-number":["AI-61479"]}]},{"name":"NIH","award":["AR-07534"],"award-info":[{"award-number":["AR-07534"]}]},{"name":"NIH","award":["AR-051461"],"award-info":[{"award-number":["AR-051461"]}]},{"DOI":"10.13039\/100000980","name":"Arthritis Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000980","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100007155","name":"Walter S. and Lucienne Driskill Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007155","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare the diagnostic accuracy and agreement of commonly available assays for anti\u2013citrullinated protein antibodies in patients with established rheumatoid arthritis (RA) and subjects at increased risk of RA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Tests for anti\u2013cyclic citrullinated peptide (anti\u2010CCP) antibodies were performed using CCP2 IgG and CCP3.1 IgA\/IgG enzyme\u2010linked immunosorbent assays in the following groups: probands with established RA (n = 340) from the Studies of the Etiology of Rheumatoid Arthritis (SERA) cohort and their first\u2010degree relatives (FDRs) without inflammatory arthritis (n = 681), Department of Defense Serum Repository (DoDSR) RA cases with pre\u2013RA diagnosis samples (n = 83; 47 cases also had post\u2013RA diagnosis samples), and blood donor and DoDSR control subjects (n = 283).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In patients with established RA, the CCP2 assay was more specific (99.2% versus 93.1%; <jats:italic>P<\/jats:italic> &lt; 0.01) but less sensitive (58.7% versus 67.4%; <jats:italic>P<\/jats:italic> = 0.01) than the CCP3.1 assay; the specificity of the CCP3.1 assay increased to 97.2% when cutoff levels \u22653\u2010fold the standard level were considered. In all subjects, CCP3.1 assay positivity (using standard cutoff levels) was more prevalent. Among DoDSR cases, the CCP2 assay was more specific than the CCP3.1 for predicting a future diagnosis of RA, and higher CCP levels trended toward increasing specificity for the development of RA within 2 years. At standard cutoff levels, assay agreement was good in patients with established RA (\u03ba = 0.76) but poor in FDRs without inflammatory arthritis (\u03ba = 0.25).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Anti\u2010CCP assays differ to an extent that may be meaningful for diagnosing RA in patients with inflammatory arthritis and evaluating the natural history of RA development in subjects at risk of RA. The mechanisms underlying these differences in test performance need further investigation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.38017","type":"journal-article","created":{"date-parts":[[2013,5,17]],"date-time":"2013-05-17T19:13:19Z","timestamp":1368817999000},"page":"2243-2252","source":"Crossref","is-referenced-by-count":70,"title":["Performance of Anti\u2013Cyclic Citrullinated Peptide Assays Differs in Subjects at Increased Risk of Rheumatoid Arthritis and Subjects With Established Disease"],"prefix":"10.1002","volume":"65","author":[{"given":"M. Kristen","family":"Demoruelle","sequence":"first","affiliation":[{"name":"University of Colorado Aurora"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark C.","family":"Parish","sequence":"additional","affiliation":[{"name":"University of Colorado Aurora"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lezlie A.","family":"Derber","sequence":"additional","affiliation":[{"name":"University of Colorado Aurora"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason R.","family":"Kolfenbach","sequence":"additional","affiliation":[{"name":"University of Colorado Aurora"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan M.","family":"Hughes\u2010Austin","sequence":"additional","affiliation":[{"name":"University of Colorado Aurora"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael H.","family":"Weisman","sequence":"additional","affiliation":[{"name":"Cedars\u2010Sinai Medical Center Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Gilliland","sequence":"additional","affiliation":[{"name":"Walter Reed National Military Medical Center Bethesda Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jess D.","family":"Edison","sequence":"additional","affiliation":[{"name":"Walter Reed National Military Medical Center Bethesda Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane H.","family":"Buckner","sequence":"additional","affiliation":[{"name":"Benaroya Research Institute at Virginia Mason Seattle Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ted R.","family":"Mikuls","sequence":"additional","affiliation":[{"name":"Omaha VA Medical Center and University of Nebraska Medical Center Omaha"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James R.","family":"O'Dell","sequence":"additional","affiliation":[{"name":"Omaha VA Medical Center and University of Nebraska Medical Center Omaha"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard M.","family":"Keating","sequence":"additional","affiliation":[{"name":"University of Chicago Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter K.","family":"Gregersen","sequence":"additional","affiliation":[{"name":"Feinstein Institute for Medical Research Manhasset New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jill M.","family":"Norris","sequence":"additional","affiliation":[{"name":"Colorado School of Public Health Aurora"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V. 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