{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:14:49Z","timestamp":1790640889180,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,7,26]],"date-time":"2013-07-26T00:00:00Z","timestamp":1374796800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Arthritis Research UK Clinical PhD Studentship","award":["18552"],"award-info":[{"award-number":["18552"]}]},{"name":"Henry Wellcome Building for Biomolecular Nuclear Magnetic Resonance Spectroscopy at the University of Birmingham"},{"name":"Wellcome Trust","award":["066490\/Z\/01\/A"],"award-info":[{"award-number":["066490\/Z\/01\/A"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Inflammatory arthritis is associated with systemic manifestations including alterations in metabolism. We used nuclear magnetic resonance (NMR) spectroscopy\u2013based metabolomics to assess metabolic fingerprints in serum from patients with established rheumatoid arthritis (RA) and those with early arthritis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Serum samples were collected from newly presenting patients with established RA who were naive for disease\u2010modifying antirheumatic drugs, matched healthy controls, and 2 groups of patients with synovitis of \u22643 months' duration whose outcomes were determined at clinical followup. Serum metabolomic profiles were assessed using 1\u2010dimensional <jats:sup>1<\/jats:sup>H\u2010NMR spectroscopy. Discriminating metabolites were identified, and the relationships between metabolomic profiles and clinical variables including outcomes were examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The serum metabolic fingerprint in established RA was clearly distinct from that of healthy controls. In early arthritis, we were able to stratify the patients according to the level of current inflammation, with C\u2010reactive protein correlating with metabolic differences in 2 separate groups (<jats:italic>P<\/jats:italic> &lt; 0.001). Lactate and lipids were important discriminators of inflammatory burden in both early arthritis patient groups. The sensitivities and specificities of models to predict the development of either RA or persistent arthritis in patients with early arthritis were low.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The metabolic fingerprint reflects inflammatory disease activity in patients with synovitis, demonstrating that underlying inflammatory processes drive significant changes in metabolism that can be measured in the peripheral blood. The identification of metabolic alterations may provide insights into disease mechanisms operating in patients with inflammatory arthritis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.38021","type":"journal-article","created":{"date-parts":[[2013,6,5]],"date-time":"2013-06-05T16:12:16Z","timestamp":1370448736000},"page":"2015-2023","source":"Crossref","is-referenced-by-count":158,"title":["The Impact of Inflammation on Metabolomic Profiles in Patients With Arthritis"],"prefix":"10.1002","volume":"65","author":[{"given":"Stephen P.","family":"Young","sequence":"first","affiliation":[{"name":"University of Birmingham Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina R.","family":"Kapoor","sequence":"additional","affiliation":[{"name":"University of Birmingham and the Sandwell and West Birmingham Hospitals NHS Trust Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark R.","family":"Viant","sequence":"additional","affiliation":[{"name":"University of Birmingham Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan J.","family":"Byrne","sequence":"additional","affiliation":[{"name":"University of Birmingham Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Filer","sequence":"additional","affiliation":[{"name":"University of Birmingham and the University Hospitals Birmingham NHS Foundation Trust Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher D.","family":"Buckley","sequence":"additional","affiliation":[{"name":"University of Birmingham and the Sandwell and West Birmingham Hospitals NHS Trust Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George D.","family":"Kitas","sequence":"additional","affiliation":[{"name":"University of Birmingham and the Dudley Group of Hospitals NHS Foundation Trust Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karim","family":"Raza","sequence":"additional","affiliation":[{"name":"University of Birmingham and the Sandwell and West Birmingham Hospitals NHS Trust Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,7,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/65.3.876"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-133-8-200010170-00015"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1202-802"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/26.2.131"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00541315"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.43.5.742"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.2174\/157016110791112269"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2008.01.015"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.122374"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27186"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr060470d"},{"key":"e_1_2_6_13_1","first-page":"1210","article-title":"Metabolomic analysis of human vitreous humor differentiates ocular inflammatory disease","volume":"15","author":"Young SP","year":"2009","journal-title":"Mol Vis"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1428"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.37921"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2008.08.001"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07762"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310302"},{"key":"e_1_2_6_19_1","first-page":"231","article-title":"Predictive value of antibodies to cyclic citrullinated peptide in patients with very early inflammatory arthritis","volume":"32","author":"Raza K","year":"2005","journal-title":"J Rheumatol"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2003.09.092"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-8-234"},{"key":"e_1_2_6_22_1","volume-title":"Multivariate calibration","author":"Martens H","year":"1989"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemolab.2004.01.003"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(02)03476-2"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11708"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkl923"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac060209g"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac00101a004"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2007.376"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1432"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr1002774"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar3243"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr070123j"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(93)81508-W"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4439(99)00020-4"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-201709"},{"key":"e_1_2_6_37_1","first-page":"1701","article-title":"Lipid profiles in untreated patients with rheumatoid arthritis","volume":"26","author":"Park YB","year":"1999","journal-title":"J Rheumatol"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-010-1436-0"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003319710373749"},{"key":"e_1_2_6_40_1","first-page":"462","article-title":"The acute phase response does not fully predict the presence of insulin resistance and dyslipidemia in inflammatory arthritis","volume":"29","author":"Dessein PH","year":"2002","journal-title":"J Rheumatol"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.53.8.551"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2008.09.009"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16449-0"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.3.1524"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.059691"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.051672"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.38021","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.38021","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T11:32:26Z","timestamp":1696591946000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.38021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,26]]},"references-count":45,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["10.1002\/art.38021"],"URL":"https:\/\/doi.org\/10.1002\/art.38021","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,26]]}}}