{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T13:23:05Z","timestamp":1779110585669,"version":"3.51.4"},"reference-count":15,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,8,26]],"date-time":"2013-08-26T00:00:00Z","timestamp":1377475200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Chronic periaortitis (CP) usually responds to glucocorticoids, but some patients have glucocorticoid\u2010refractory disease or contraindications to glucocorticoid therapy. This study was undertaken to evaluate treatment with the anti\u2013interleukin\u20106 receptor (anti\u2013IL\u20106R) antibody tocilizumab in 2 patients with CP, one with refractory disease and the other with contraindications to glucocorticoids, and to assess IL\u20106 levels in an additional cohort of patients with CP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Both patients were given intravenous tocilizumab (8 mg\/kg) once every 4 weeks for 6 months. Serum IL\u20106 was measured in 22 patients with active CP and 16 healthy controls. Tissue IL\u20106 expression was assessed by confocal microscopy in biopsy specimens obtained from 6 patients with CP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the first patient, whose disease was refractory to various immunosuppressive treatments, tocilizumab added to ongoing therapy with prednisone and methotrexate allowed prednisone withdrawal and induced resolution of symptoms, acute\u2010phase reactant normalization, and reduction in <jats:sup>18<\/jats:sup>F\u2010fluorodeoxyglucose (<jats:sup>18<\/jats:sup>F\u2010FDG) uptake on positron emission tomography. The patient experienced a relapse 7 months later and was successfully retreated with tocilizumab. In the second patient, who was unable to tolerate glucocorticoids because of psychiatric side effects, tocilizumab monotherapy induced sustained clinical and laboratory remission, <jats:sup>18<\/jats:sup>F\u2010FDG uptake disappearance, and CP shrinkage. Serum IL\u20106 levels were significantly higher in patients with active CP than in controls (<jats:italic>P<\/jats:italic> &lt; 0.0001), and IL\u20106 was abundantly expressed in biopsy specimens from CP patients, particularly by T cells, B cells, histiocytes, fibroblasts, and vascular smooth muscle cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Tocilizumab may be a therapeutic option for CP. The systemic and tissue up\u2010regulation of IL\u20106 in CP, together with the clinical benefit of IL\u20106R blockade observed in our 2 patients, suggest that IL\u20106 may contribute to CP pathogenesis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.38032","type":"journal-article","created":{"date-parts":[[2013,6,5]],"date-time":"2013-06-05T16:12:31Z","timestamp":1370448751000},"page":"2469-2475","source":"Crossref","is-referenced-by-count":60,"title":["Brief Report: Interleukin\u20106 as an Inflammatory Mediator and Target of Therapy in Chronic Periaortitis"],"prefix":"10.1002","volume":"65","author":[{"given":"Augusto","family":"Vaglio","sequence":"first","affiliation":[{"name":"University Hospital of Parma Parma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria G.","family":"Catanoso","sequence":"additional","affiliation":[{"name":"Arcispedale S. Maria Nuova, IRCCS Reggio Emilia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"Spaggiari","sequence":"additional","affiliation":[{"name":"Arcispedale S. Maria Nuova, IRCCS Reggio Emilia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Magnani","sequence":"additional","affiliation":[{"name":"Arcispedale S. Maria Nuova, IRCCS Reggio Emilia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicol\u00f2","family":"Pipitone","sequence":"additional","affiliation":[{"name":"Arcispedale S. Maria Nuova, IRCCS Reggio Emilia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierluigi","family":"Macchioni","sequence":"additional","affiliation":[{"name":"Arcispedale S. 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Maria Nuova, IRCCS Reggio Emilia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Boiardi","sequence":"additional","affiliation":[{"name":"Arcispedale S. Maria Nuova, IRCCS Reggio Emilia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Salvarani","sequence":"additional","affiliation":[{"name":"Arcispedale S. 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