{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:46:35Z","timestamp":1791899195395,"version":"4.3.4"},"reference-count":48,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,9,24]],"date-time":"2013-09-24T00:00:00Z","timestamp":1379980800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Arthrogenic alphaviruses such as Ross River virus (RRV) and chikungunya virus (CHIKV) circulate worldwide. This virus class causes debilitating illnesses that are characterized by arthritis, arthralgia, and myalgia. In previous studies, we identified macrophage migration inhibitory factor (MIF) as a critical inflammatory factor in the pathogenesis of alphaviral diseases. The present study was undertaken to characterize the role of CD74, a cell surface receptor of MIF, in both RRV\u2010 and CHIKV\u2010induced alphavirus arthritides.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Mouse models of RRV and CHIKV infection were used to investigate the immunopathogenesis of arthritic alphavirus infection. The role of CD74 was assessed using histologic analysis, real\u2010time polymerase chain reaction, flow cytometry, and plaque assay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In comparison to wild\u2010type mice, CD74<jats:sup>\u2212\/\u2212<\/jats:sup> mice developed only mild clinical features and had low levels of tissue damage. Leukocyte infiltration, characterized predominantly by inflammatory monocytes and natural killer cells, was substantially reduced in the infected tissue of CD74<jats:sup>\u2212\/\u2212<\/jats:sup> mice, but production of proinflammatory cytokines and chemokines was not decreased. CD74 deficiency was associated with increased monocyte apoptosis, but had no effect on monocyte migratory capacity. Consistent with these findings, alphaviral infection resulted in a dose\u2010dependent up\u2010regulation of CD74 expression in human peripheral blood mononuclear cells, and serum MIF levels were significantly elevated in patients with RRV or CHIKV infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CD74 appears to regulate immune responses to alphaviral infection through its effects on cellular recruitment and survival. These findings suggest that both MIF and CD74 play a critical role in mediating alphaviral disease, and blocking these factors with novel therapeutic agents could substantially ameliorate the pathologic manifestations.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.38090","type":"journal-article","created":{"date-parts":[[2013,7,29]],"date-time":"2013-07-29T14:43:46Z","timestamp":1375109026000},"page":"2724-2736","source":"Crossref","is-referenced-by-count":50,"title":["Macrophage Migration Inhibitory Factor Receptor CD74 Mediates Alphavirus\u2010Induced Arthritis and Myositis in Murine Models of Alphavirus Infection"],"prefix":"10.1002","volume":"65","author":[{"given":"Lara J.","family":"Herrero","sequence":"first","affiliation":[{"name":"Griffith University, Gold Coast Campus Southport, Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuo\u2010Ching","family":"Sheng","sequence":"additional","affiliation":[{"name":"Griffith University, Gold Coast Campus Southport, Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Jian","sequence":"additional","affiliation":[{"name":"Griffith University, Gold Coast Campus Southport, Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Taylor","sequence":"additional","affiliation":[{"name":"Griffith University, Gold Coast Campus Southport, Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhisheng","family":"Her","sequence":"additional","affiliation":[{"name":"Singapore Immunology Network, Agency for Science, Technology and Research, and Yong Loo Lin School of Medicine, National University of Singapore Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belinda L.","family":"Herring","sequence":"additional","affiliation":[{"name":"Griffith University, Gold Coast Campus Southport, Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Chow","sequence":"additional","affiliation":[{"name":"Tan Tock Seng Hospital Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yee\u2010Sin","family":"Leo","sequence":"additional","affiliation":[{"name":"Tan Tock Seng Hospital Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Hickey","sequence":"additional","affiliation":[{"name":"Monash University Clayton, Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric F.","family":"Morand","sequence":"additional","affiliation":[{"name":"Monash University Clayton, Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa F. P.","family":"Ng","sequence":"additional","affiliation":[{"name":"Singapore Immunology Network, Agency for Science, Technology and Research, and Yong Loo Lin School of Medicine, National University of Singapore Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Bucala","sequence":"additional","affiliation":[{"name":"Yale University School of Medicine New Haven Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suresh","family":"Mahalingam","sequence":"additional","affiliation":[{"name":"Griffith University, Gold Coast Campus Southport, Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,9,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.bor.0000130537.76808.26"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1408.007"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2009.09.005"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2007.77.727"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60281-X"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1212.060710"},{"key":"e_1_2_7_8_1","first-page":"315","article-title":"Chikungunya epidemic: an Indian perspective","volume":"19","author":"Kalantri SP","year":"2006","journal-title":"Natl Med J India"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1210.060529"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3855\/jidc.2171"},{"key":"e_1_2_7_11_1","unstructured":"SetepanoN. New disease enters PNG. Post\u2010Curier Online2012. URL:http:\/\/www.postcourier.com.pg\/20121010\/news09.htm."},{"key":"e_1_2_7_12_1","unstructured":"FloresH. Cases of dengue\u2010like virus rising. Philippine Star 2012. URL:http:\/\/www.philstar.com\/headlines\/2012\/10\/09\/857603\/doh\u2010cases\u2010dengue\u2010virus\u2010rising."},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1803.110838"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001918"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.14.4.909-932.2001"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1086\/315164"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1086\/587841"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02799-06"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.80.2.737-749.2006"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002586"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00601-12"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1101089108"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1200"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1517\/14728222.2011.550879"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M703265200"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20030286"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2010.08.013"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2006.08.020"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0701553104"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1567"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1003713"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2009.07.058"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(91)90584-X"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiq042"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI63120"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jis033"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1533295100"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02603-09"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0900255"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.177.6.1699"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.4.1610"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep00058"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.7.4818"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI1524"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.2.1355"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01352-08"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.012511599"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.4110\/in.2010.10.3.92"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2009.03.007"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.38090","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.38090","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T21:11:52Z","timestamp":1696540312000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.38090"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9,24]]},"references-count":48,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["10.1002\/art.38090"],"URL":"https:\/\/doi.org\/10.1002\/art.38090","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9,24]]}}}