{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T07:39:15Z","timestamp":1780472355923,"version":"3.54.1"},"reference-count":39,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2013,11,27]],"date-time":"2013-11-27T00:00:00Z","timestamp":1385510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To identify new genetic associations with juvenile and adult dermatomyositis (DM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a genome\u2010wide association study (GWAS) of adult and juvenile DM patients of European ancestry (n = 1,178) and controls (n = 4,724). To assess genetic overlap with other autoimmune disorders, we examined whether 141 single\u2010nucleotide polymorphisms (SNPs) outside the major histocompatibility complex (MHC) locus, and previously associated with autoimmune diseases, predispose to DM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to controls, patients with DM had a strong signal in the MHC region consisting of GWAS\u2010level significance (<jats:italic>P<\/jats:italic> &lt; 5 \u00d7 10<jats:sup>\u20138<\/jats:sup>) at 80 genotyped SNPs. An analysis of 141 non\u2010MHC SNPs previously associated with autoimmune diseases showed that 3 SNPs linked with 3 genes were associated with DM, with a false discovery rate (FDR) of &lt;0.05. These genes were phospholipase C\u2013like 1 (<jats:italic>PLCL1<\/jats:italic>; rs6738825, FDR = 0.00089), B lymphoid tyrosine kinase (<jats:italic>BLK<\/jats:italic>; rs2736340, FDR = 0.0031), and chemokine (C\u2010C motif) ligand 21 (<jats:italic>CCL21<\/jats:italic>; rs951005, FDR = 0.0076). None of these genes was previously reported to be associated with DM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings confirm the MHC as the major genetic region associated with DM and indicate that DM shares non\u2010MHC genetic features with other autoimmune diseases, suggesting the presence of additional novel risk loci. This first identification of autoimmune disease genetic predispositions shared with DM may lead to enhanced understanding of pathogenesis and novel diagnostic and therapeutic approaches.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.38137","type":"journal-article","created":{"date-parts":[[2013,8,27]],"date-time":"2013-08-27T20:48:49Z","timestamp":1377636529000},"page":"3239-3247","source":"Crossref","is-referenced-by-count":128,"title":["Genome\u2010Wide Association Study of Dermatomyositis Reveals Genetic Overlap With Other Autoimmune Disorders"],"prefix":"10.1002","volume":"65","author":[{"given":"Frederick W.","family":"Miller","sequence":"first","affiliation":[{"name":"National Institute of Environmental Health Sciences, NIH Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert G.","family":"Cooper","sequence":"additional","affiliation":[{"name":"University of Manchester Manchester UK"},{"name":"Salford Royal National Health Service Foundation Trust Salford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji\u0159\u00ed","family":"Vencovsk\u00fd","sequence":"additional","affiliation":[{"name":"Institute of Rheumatology Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa G.","family":"Rider","sequence":"additional","affiliation":[{"name":"National Institute of Environmental Health Sciences, NIH Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katalin","family":"Danko","sequence":"additional","affiliation":[{"name":"University of Debrecen Debrecen Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy R.","family":"Wedderburn","sequence":"additional","affiliation":[{"name":"University College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid E.","family":"Lundberg","sequence":"additional","affiliation":[{"name":"Karolinska University Hospital Solna Sweden"},{"name":"Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren M.","family":"Pachman","sequence":"additional","affiliation":[{"name":"Children's Hospital of Chicago and Northwestern University Feinberg School of Medicine Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann M.","family":"Reed","sequence":"additional","affiliation":[{"name":"Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven R.","family":"Ytterberg","sequence":"additional","affiliation":[{"name":"Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonid","family":"Padyukov","sequence":"additional","affiliation":[{"name":"Karolinska University Hospital Solna Sweden"},{"name":"Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Selva\u2010O'Callaghan","sequence":"additional","affiliation":[{"name":"Vall d'Hebron General Hospital Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy R. 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