{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T11:25:04Z","timestamp":1788521104711,"version":"build-2803163510"},"reference-count":44,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,3,28]],"date-time":"2014-03-28T00:00:00Z","timestamp":1395964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000097","name":"NIH (National Center for Research Resources)","doi-asserted-by":"crossref","award":["UL1-RR-025005"],"award-info":[{"award-number":["UL1-RR-025005"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"crossref"}]},{"name":"NIH Roadmap for Medical Research"},{"name":"NIH","award":["P30-AR-053503"],"award-info":[{"award-number":["P30-AR-053503"]}]},{"name":"NIH","award":["AR-43727"],"award-info":[{"award-number":["AR-43727"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To characterize peripheral neuropathy subtypes, ancillary studies, and immunologic profiles associated with peripheral neuropathies in patients with systemic lupus erythematosus (SLE).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this 25\u2010year study of 2,097 SLE patients, we characterized peripheral neuropathies due to SLE and compared clinical and SLE\u2010related features in patients with versus those without neuropathy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The prevalence of peripheral neuropathies was 5.9% (123 of 2,097 patients), and 66.7% of these patients (82 of 123) had peripheral neuropathies attributable to SLE. We noted that 17.1% of the patients with peripheral neuropathies due to SLE (14 of 82 patients) had small\u2010fiber neuropathy, which is a painful neuropathy not included in the American College of Rheumatology (ACR) neuropsychiatric SLE (NPSLE) case definitions. SLE patients with small\u2010fiber neuropathies could present with unorthodox neuropathic pain patterns not consistent with a stocking\u2013glove distribution and had associated skin biopsy results suggestive of dorsal root ganglion neuronal cell loss. Compared to SLE patients without peripheral neuropathies, those with peripheral neuropathies had lower mean disease activity (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.01) and higher disease damage (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.01) and were more likely to have a history of herpes zoster virus infection (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.01), osteoporotic fractures (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.01), and opportunistic infections (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings indicate that small\u2010fiber neuropathy is a frequently occurring peripheral neuropathy. The skin biopsy findings in small\u2010fiber neuropathy patients support the notion that distinct mechanisms target the dorsal root ganglia as well as distal axons. SLE patients with peripheral neuropathy have lower mean disease activity scores and higher disease damage. Our findings suggest that revision of the ACR NPSLE case definitions, which currently do not include small\u2010fiber neuropathies, is warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.38302","type":"journal-article","created":{"date-parts":[[2013,12,10]],"date-time":"2013-12-10T14:46:58Z","timestamp":1386686818000},"page":"1000-1009","source":"Crossref","is-referenced-by-count":102,"title":["Peripheral Neuropathies in Systemic Lupus Erythematosus: Clinical Features, Disease Associations, and Immunologic Characteristics Evaluated Over a Twenty\u2010Five\u2013Year Study Period"],"prefix":"10.1002","volume":"66","author":[{"given":"A.","family":"Oomatia","sequence":"first","affiliation":[{"name":"University of Cambridge School of Clinical Medicine Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Fang","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine Baltimore 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