{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:47:21Z","timestamp":1792036041089,"version":"4.4.0"},"reference-count":56,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,4,28]],"date-time":"2014-04-28T00:00:00Z","timestamp":1398643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To examine the degree to which shared risk factors explain the relationship of periodontitis (PD) to rheumatoid arthritis (RA) and to determine the associations of PD and\n                      <jats:italic>Porphyromonas gingivalis<\/jats:italic>\n                      with pathologic and clinical features of RA.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Patients with RA (n = 287) and patients with osteoarthritis as disease controls (n = 330) underwent a standardized periodontal examination. The\n                      <jats:italic>HLA\u2013DRB1<\/jats:italic>\n                      status of all participants was imputed using single\u2010nucleotide polymorphisms from the extended major histocompatibility complex. Circulating anti\u2013\n                      <jats:italic>P gingivalis<\/jats:italic>\n                      antibodies were measured using an enzyme\u2010linked immunosorbent assay, and subgingival plaque was assessed for the presence of\n                      <jats:italic>P gingivalis<\/jats:italic>\n                      using polymerase chain reaction (PCR). Associations of PD with RA were examined using multivariable regression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Presence of PD was more common in patients with RA and patients with anti\u2013citrullinated protein antibody (ACPA)\u2013positive RA (n = 240; determined using the anti\u2013cyclic citrullinated peptide 2 [anti\u2013CCP\u20102] test) than in controls (35% and 37%, respectively, versus 26%;\n                      <jats:italic>P<\/jats:italic>\n                      = 0.022 and\n                      <jats:italic>P<\/jats:italic>\n                      = 0.006, respectively). There were no differences between RA patients and controls in the levels of anti\u2013\n                      <jats:italic>P gingivalis<\/jats:italic>\n                      or the frequency of\n                      <jats:italic>P gingivalis<\/jats:italic>\n                      positivity by PCR. The anti\u2013\n                      <jats:italic>P gingivalis<\/jats:italic>\n                      findings showed a weak, but statistically significant, association with the findings for both anti\u2013CCP\u20102 (r = 0.14,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.022) and rheumatoid factor (RF) (r = 0.19,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.001). Presence of PD was associated with increased swollen joint counts (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.004), greater disease activity according to the 28\u2010joint Disease Activity Score using C\u2010reactive protein level (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.045), and higher total Sharp scores of radiographic damage (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.015), as well as with the presence and levels of anti\u2013CCP\u20102 (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.011) and RF (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001). The expression levels of select ACPAs (including antibodies to citrullinated filaggrin) were higher in patients with subgingival\n                      <jats:italic>P gingivalis<\/jats:italic>\n                      and in those with higher levels of anti\u2013\n                      <jats:italic>P gingivalis<\/jats:italic>\n                      antibodies, irrespective of smoking status. Associations of PD with established seropositive RA were independent of all covariates examined, including evidence of\n                      <jats:italic>P gingivalis<\/jats:italic>\n                      infection.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Both PD and\n                      <jats:italic>P gingivalis<\/jats:italic>\n                      appear to shape the autoreactivity of RA. In addition, these results demonstrate an independent relationship between PD and established seropositive RA.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.38348","type":"journal-article","created":{"date-parts":[[2014,1,8]],"date-time":"2014-01-08T10:14:07Z","timestamp":1389176047000},"page":"1090-1100","source":"Crossref","is-referenced-by-count":357,"title":["Periodontitis and\n                    <i>Porphyromonas gingivalis<\/i>\n                    in Patients With Rheumatoid Arthritis"],"prefix":"10.1002","volume":"66","author":[{"given":"Ted R.","family":"Mikuls","sequence":"first","affiliation":[{"name":"Omaha VA Medical Center and University of Nebraska Medical Center Omaha"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey B.","family":"Payne","sequence":"additional","affiliation":[{"name":"University of Nebraska Medical Center Lincoln"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Yu","sequence":"additional","affiliation":[{"name":"University of Nebraska Medical Center Omaha"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey M.","family":"Thiele","sequence":"additional","affiliation":[{"name":"Omaha VA Medical Center and University of Nebraska Medical Center Omaha"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Reynolds","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grant W.","family":"Cannon","sequence":"additional","affiliation":[{"name":"George Wahlen VA Medical Center Salt Lake City Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Markt","sequence":"additional","affiliation":[{"name":"University of Nebraska Medical Center Omaha"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"McGowan","sequence":"additional","affiliation":[{"name":"George Wahlen VA Medical Center Salt Lake City Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gail S.","family":"Kerr","sequence":"additional","affiliation":[{"name":"Washington DC VA Medical Center Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert S.","family":"Redman","sequence":"additional","affiliation":[{"name":"Washington DC VA Medical Center Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Reimold","sequence":"additional","affiliation":[{"name":"Dallas VA Medical Center Dallas Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garth","family":"Griffiths","sequence":"additional","affiliation":[{"name":"Dallas VA Medical Center Dallas Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Beatty","sequence":"additional","affiliation":[{"name":"Omaha VA Medical Center Omaha Nebraska"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shawneen M.","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"University of Nebraska Medical Center Lincoln"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debra A.","family":"Bergman","sequence":"additional","affiliation":[{"name":"Omaha VA Medical Center and University of Nebraska Medical Center Omaha"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Bartlett C.","family":"Hamilton","sequence":"additional","affiliation":[{"name":"Omaha VA Medical Center and University of Nebraska Medical Center Omaha"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan R.","family":"Erickson","sequence":"additional","affiliation":[{"name":"Omaha VA Medical Center and University of Nebraska Medical Center Omaha"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Sokolove","sequence":"additional","affiliation":[{"name":"Palo Alto VA Medical Center and Stanford University Palo Alto California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William H.","family":"Robinson","sequence":"additional","affiliation":[{"name":"Palo Alto VA Medical Center and Stanford University Palo Alto California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clay","family":"Walker","sequence":"additional","affiliation":[{"name":"University of Florida Gainesville"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatiha","family":"Chandad","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Laval Qu\u00e9bec, Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James R.","family":"O'Dell","sequence":"additional","affiliation":[{"name":"Omaha VA Medical Center and University of Nebraska Medical Center Omaha"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,4,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2010.07.011"},{"key":"e_1_2_6_3_1","first-page":"354","volume-title":"Host\u2010parasite interactions in periodontal diseases","author":"Snyderman R","year":"1982"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.12.1874"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.1999.260203.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2002.290815.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(02)01051-3"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780301102"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199905)42:5<910::AID-ANR9>3.0.CO;2-D"},{"key":"e_1_2_6_10_1","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/S0889-857X(21)00151-4","article-title":"Prediction of susceptibility to rheumatoid arthritis by human leukocyte antigen genotyping","volume":"18","author":"Nepom GT","year":"1992","journal-title":"Rheum Dis Clin North Am"},{"key":"e_1_2_6_11_1","first-page":"585","article-title":"HLA heterozygosity contributes to susceptibility to rheumatoid arthritis","volume":"51","author":"Wordsworth P","year":"1992","journal-title":"Am J Hum Genet"},{"key":"e_1_2_6_12_1","first-page":"70","article-title":"Association of periodontal disease and tooth loss with rheumatoid arthritis in the US population","volume":"35","author":"Pablo P","year":"2008","journal-title":"J Rheumatol"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.090309"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780401221"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.3109\/03009747509095615"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.070501"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-200380"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.34539"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar4061"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-004-6641-z"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2012.01885.x"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.091323"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2008.09.008"},{"key":"e_1_2_6_24_1","first-page":"2","article-title":"Serum antibodies to oral anaerobic bacteria in patients with rheumatoid arthritis","volume":"7","author":"Ogrendik M","year":"2005","journal-title":"MedGenMed"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12002"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.34595"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310302"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2010.0255"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.5435\/JAAOS-21-03-180"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1992.63.3.206"},{"key":"e_1_2_6_31_1","first-page":"83","article-title":"Assessment criteria for compliance with oral hygiene: application of ROC analysis","volume":"5","author":"Htoon HM","year":"2007","journal-title":"Oral Health Prev Dent"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.070015"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.054924"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780380107"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/38.10.941"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.1991.tb00502.x"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034510370817"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1988.tb01590.x"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0928-8244(03)00224-4"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btr061"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2007.09.001"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar3190"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.091062498"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.120899"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034513483142"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.5.743"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.060435"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.091398"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2009.01393.x"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2012.01889.x"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.122739"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-202726"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27552"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2011.06.006"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0018679"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1159\/000329672"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.33432"}],"container-title":["Arthritis &amp; Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.38348","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.38348","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:59:55Z","timestamp":1759946395000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/art.38348"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4,28]]},"references-count":56,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["10.1002\/art.38348"],"URL":"https:\/\/doi.org\/10.1002\/art.38348","archive":["Portico"],"relation":{},"ISSN":["2326-5191","2326-5205"],"issn-type":[{"value":"2326-5191","type":"print"},{"value":"2326-5205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,28]]}}}