{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T02:32:27Z","timestamp":1791340347815,"version":"4.3.1"},"reference-count":39,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,6,27]],"date-time":"2014-06-27T00:00:00Z","timestamp":1403827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Soci\u00ef\u00bf\u00bdt\u00ef\u00bf\u00bd Fran\u00ef\u00bf\u00bdaise de Rhumatologie","award":["M2 2013-2014"],"award-info":[{"award-number":["M2 2013-2014"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To estimate the frequency of use and effectiveness in daily practice of tumor necrosis factor \u03b1 (TNF\u03b1) blockers in a population with inflammatory back pain suggestive of early axial spondyloarthritis (SpA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Devenir des Spondylarthropathies Indiff\u00e9renci\u00e9es R\u00e9centes (DESIR) cohort is a prospective, multicenter, observational cohort of 708 patients with early (&lt;3 years' duration) inflammatory back pain suggestive of axial SpA. The percentage of patients receiving TNF\u03b1 blockers over the first 2 years of followup was estimated by survival analysis. To evaluate effectiveness, the primary outcome (40% improvement in disease activity according to the Assessment of SpondyloArthritis international Society criteria [ASAS40]) was compared in patients who received TNF\u03b1 blockers versus control patients who received any other treatment (usual care). Controls were matched to the patients based on a propensity score method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 30.2% (95% confidence interval [95% CI] 26.7\u201333.7) patients received at least 1 TNF\u03b1 blocker during the 24 months of followup. The percentage of ASAS40 responders was 31.5% (62 of 197 patients) in the group receiving TNF\u03b1 blockers versus 13.2% (26 of 197) in the control group (OR 2.99 [95% CI 1.80\u20134.99], <jats:italic>P<\/jats:italic> = 0.0002). This effectiveness was more pronounced in the subgroup of patients with sacroiliitis identified on magnetic resonance imaging, with 46% of ASAS40 responders receiving TNF\u03b1 blockers versus 15% of ASAS40 responders receiving usual care (OR 4.99 [95% CI 2.17\u201311.51]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study shows that TNF\u03b1 blockers are frequently used in daily practice to treat patients with early axial SpA. Our findings confirm the effectiveness of TNF\u03b1 blockers as compared to any other treatment, especially in the subgroup of patients with sacroiliitis on MRI.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.38613","type":"journal-article","created":{"date-parts":[[2014,3,12]],"date-time":"2014-03-12T10:51:21Z","timestamp":1394621481000},"page":"1734-1744","source":"Crossref","is-referenced-by-count":35,"title":["Effectiveness of Tumor Necrosis Factor \u03b1 Blockers in Early Axial Spondyloarthritis: Data From the DESIR Cohort"],"prefix":"10.1002","volume":"66","author":[{"given":"Anna","family":"Molt\u00f3","sequence":"first","affiliation":[{"name":"Paris Descartes University, Cochin Hospital, AP\u2010HP, INSERM U1153, PRES Sorbonne Paris Cit\u00e9 Paris France"},{"name":"Universitat Autonoma de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Paternotte","sequence":"additional","affiliation":[{"name":"Paris Descartes University, Cochin Hospital, AP\u2010HP, INSERM U1153, and PRES Sorbonne Paris\u2010Cit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Claudepierre","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Est Cr\u00e9teil, EA4393, and Henri\u2010Mondor Hospital, AP\u2010HP Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxime","family":"Breban","sequence":"additional","affiliation":[{"name":"University of Versailles St.\u2010Quentin\u2010en\u2010Yvelines and Ambroise Par\u00e9 Hospital, AP\u2010HP Boulogne\u2010Billancourt France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxime","family":"Dougados","sequence":"additional","affiliation":[{"name":"Paris Descartes University, Cochin Hospital, AP\u2010HP, INSERM U1153, and PRES Sorbonne Paris\u2010Cit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,6,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780270401"},{"key":"e_1_2_8_3_1","first-page":"85","article-title":"Crit\u00e8res de classification des spondylarthropathies","volume":"57","author":"Amor B","year":"1990","journal-title":"Rev Rhum Mal Osteoartic"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780341003"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.108233"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kes026"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.11104"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.020875"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-200358"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.23606"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-201766"},{"key":"e_1_2_8_12_1","first-page":"S642","article-title":"Safety and efficacy of etanercept in early non\u2010radiographic axial spondyloarthritis: a randomized, double\u2010blind, placebo\u2010controlled trial at 24 weeks","volume":"65","author":"Dougados M","year":"2013","journal-title":"Arthritis Rheum"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar3369"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kep422"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.147744"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.081048"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.38140"},{"key":"e_1_2_8_18_1","unstructured":"DESIR in English. 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