{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:57:26Z","timestamp":1792789046660,"version":"4.5.0"},"reference-count":48,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,6,27]],"date-time":"2014-06-27T00:00:00Z","timestamp":1403827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Dutch Arthritis Association (NC Smit fonds)","award":["grant 9-1-201"],"award-info":[{"award-number":["grant 9-1-201"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Several lines of evidence indicate that B cells may be involved in the immunopathology of giant cell arteritis (GCA) and polymyalgia rheumatica (PMR). This study was undertaken to examine the distribution of defined B cell subsets, including effector B (Beff) cells and regulatory B (Breg) cells, in patients with GCA and patients with PMR before and after corticosteroid treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Circulating B cells were analyzed in 34 newly diagnosed, untreated patients with GCA or PMR, and in 44 followup samples from patients with GCA or PMR who received corticosteroids for 2 weeks or 3 months. For comparison, 40 age\u2010matched healthy controls and 11 rheumatoid arthritis (RA) patients were included. Serum BAFF levels were determined, and temporal arteries were studied by immunohistochemistry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Patients newly diagnosed as having GCA or PMR, but not patients with RA, had decreased numbers of circulating B cells compared to healthy controls. B cell numbers recovered rapidly in treated patients with GCA and PMR in remission. This recovery was not achieved by compensatory hyperproliferation or enhanced bone marrow production. B cell numbers inversely correlated with erythrocyte sedimentation rates, C\u2010reactive protein levels, and serum BAFF levels. Tumor necrosis factor \u03b1\u2013positive Beff cells, but not interleukin\u201010 (IL\u201010)\u2013positive Breg cells, were decreased in patients newly diagnosed as having GCA or PMR. Following treatment, circulating numbers of Beff cells normalized. The returning Beff cells demonstrated an enhanced capacity to produce IL\u20106. Few B cells were found in temporal artery biopsy specimens from GCA patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We show for the first time that the distribution of B cells is highly disturbed in GCA and PMR and that B cells likely contribute to the enhanced IL\u20106 response in both diseases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.38625","type":"journal-article","created":{"date-parts":[[2014,3,12]],"date-time":"2014-03-12T10:51:48Z","timestamp":1394621508000},"page":"1927-1938","source":"Crossref","is-referenced-by-count":120,"title":["Disturbed B Cell Homeostasis in Newly Diagnosed Giant Cell Arteritis and Polymyalgia Rheumatica"],"prefix":"10.1002","volume":"66","author":[{"given":"Kornelis S. M.","family":"van der Geest","sequence":"first","affiliation":[{"name":"University of Groningen and University Medical Center Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayel H.","family":"Abdulahad","sequence":"additional","affiliation":[{"name":"University of Groningen and University Medical Center Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulina","family":"Chalan","sequence":"additional","affiliation":[{"name":"University of Groningen and University Medical Center Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abraham","family":"Rutgers","sequence":"additional","affiliation":[{"name":"University of Groningen and University Medical Center Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerda","family":"Horst","sequence":"additional","affiliation":[{"name":"University of Groningen and University Medical Center Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minke G.","family":"Huitema","sequence":"additional","affiliation":[{"name":"University of Groningen and University Medical Center Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirjam P.","family":"Roffel","sequence":"additional","affiliation":[{"name":"University of Groningen and University Medical Center Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Roozendaal","sequence":"additional","affiliation":[{"name":"University of Groningen and University Medical Center Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip M.","family":"Kluin","sequence":"additional","affiliation":[{"name":"University of Groningen and University Medical Center Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolaas A.","family":"Bos","sequence":"additional","affiliation":[{"name":"University of Groningen and University Medical Center Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annemieke M. H.","family":"Boots","sequence":"additional","affiliation":[{"name":"University of Groningen and University Medical Center Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Brouwer","sequence":"additional","affiliation":[{"name":"University of Groningen and University Medical Center Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,6,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24459"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61077-6"},{"key":"e_1_2_9_4_1","first-page":"1283","article-title":"Analysis of steroid related complications and mortality in temporal arteritis: a 15\u2010year survey of 43 patients","volume":"21","author":"Nesher G","year":"1994","journal-title":"J Rheumatol"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2013.161"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780390719"},{"key":"e_1_2_9_7_1","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1002\/j.2326-5205.1989.tb00020.x","article-title":"Immunohistochemical analysis of lymphoid and macrophage cell subsets and their immunologic activation markers in temporal arteritis: influence of corticosteroid treatment","volume":"32","author":"Cid MC","year":"1989","journal-title":"Arthritis Rheum"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780261005"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.100455"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.46.12.915"},{"key":"e_1_2_9_11_1","first-page":"1011","article-title":"The inflammatory infiltrate in giant cell arteritis selects against B lymphocytes","volume":"23","author":"Martinez\u2010Taboada V","year":"1996","journal-title":"J Rheumatol"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar3388"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-200413"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2002.01751.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2012.10.003"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-202963"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-81-1-19"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.37.3.238"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2005.036533"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0909905"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2011.153007"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2009.11.009"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-07-294249"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/82717"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20111675"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780330810"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-97-5-672"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.30236"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2012.00302"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-06-361881"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1102321"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-202071"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-12-017319"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar3493"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2729"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0691.2003.00518.x"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/22.6.1096"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1177\/153537020222700907"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1982.tb00431.x"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2009.018689"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111757"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar2076"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2003.018663"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2572"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.23.021704.115732"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-04-345579"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-07-440776"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-202986"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.34647"}],"container-title":["Arthritis &amp; Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.38625","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.38625","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T14:45:14Z","timestamp":1759934714000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/art.38625"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,27]]},"references-count":48,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["10.1002\/art.38625"],"URL":"https:\/\/doi.org\/10.1002\/art.38625","archive":["Portico"],"relation":{},"ISSN":["2326-5191","2326-5205"],"issn-type":[{"value":"2326-5191","type":"print"},{"value":"2326-5205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,27]]}}}