{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T13:04:31Z","timestamp":1770123871381,"version":"3.49.0"},"reference-count":34,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,6,27]],"date-time":"2014-06-27T00:00:00Z","timestamp":1403827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["AI 056363"],"award-info":[{"award-number":["AI 056363"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"name":"German Research Foundation (DFG) to the collaborative research center SFB 765"},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology of Japan","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Ministry of Health, Labor and Welfare of Japan"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the role of adhesion molecules in C protein\u2013induced myositis (CIM), a murine model of polymyositis (PM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>CIM was induced in wild\u2010type mice, L\u2010selectin\u2013deficient (L\u2010selectin<jats:sup>\u2212\/\u2212<\/jats:sup>) mice, intercellular adhesion molecule 1 (ICAM\u20101)\u2013deficient (ICAM\u20101<jats:sup>\u2212\/\u2212<\/jats:sup>) mice, and mice deficient in both L\u2010selectin and ICAM\u20101 (L\u2010selectin<jats:sup>\u2212\/\u2212<\/jats:sup>ICAM\u20101<jats:sup>\u2212\/\u2212<\/jats:sup> mice). Myositis severity, inflammatory cell infiltration, and messenger RNA expression in the inflamed muscles were analyzed. The effect of dendritic polyglycerol sulfate, a synthetic inhibitor that suppresses the function of L\u2010selectin and endothelial P\u2010selectin, was also examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>L\u2010selectin<jats:sup>\u2212\/\u2212<\/jats:sup> mice and L\u2010selectin<jats:sup>\u2212\/\u2212<\/jats:sup>ICAM\u20101<jats:sup>\u2212\/\u2212<\/jats:sup> mice developed significantly less severe myositis compared to wild\u2010type mice, while ICAM\u20101 deficiency did not inhibit the development of myositis. L\u2010selectin<jats:sup>\u2212\/\u2212<\/jats:sup> mice that received wild\u2010type T cells developed myositis. Treatment with dendritic polyglycerol sulfate significantly diminished the severity of myositis in wild\u2010type mice compared to treatment with control.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These data indicate that L\u2010selectin plays a major role in the development of CIM, whereas ICAM\u20101 plays a lesser role, if any, in the development of CIM. L\u2010selectin\u2013targeted therapy may be a candidate for the treatment of PM.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.38630","type":"journal-article","created":{"date-parts":[[2014,3,18]],"date-time":"2014-03-18T14:07:33Z","timestamp":1395151653000},"page":"1864-1871","source":"Crossref","is-referenced-by-count":16,"title":["A Crucial Role of L\u2010Selectin in C Protein\u2013Induced Experimental Polymyositis in Mice"],"prefix":"10.1002","volume":"66","author":[{"given":"Kyosuke","family":"Oishi","sequence":"first","affiliation":[{"name":"Kanazawa University Kanazawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhito","family":"Hamaguchi","sequence":"additional","affiliation":[{"name":"Kanazawa University Kanazawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Matsushita","sequence":"additional","affiliation":[{"name":"Kanazawa University Kanazawa 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