{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T23:15:39Z","timestamp":1782774939497,"version":"3.54.5"},"reference-count":39,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,7,28]],"date-time":"2014-07-28T00:00:00Z","timestamp":1406505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Physicians Services Incorporated (PSI)","award":["05-02"],"award-info":[{"award-number":["05-02"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the impact of prenatal exposure to maternal anti\u2010Ro antibodies, slow fetal heart rate, and\/or prolonged dexamethasone therapy for immune\u2010mediated congenital atrioventricular heart block (CAVB) on the cognitive and academic performance of these children at school age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a prospective, blinded assessment of the cognitive functioning of 3 cohorts of children ages 6\u201316 years with in utero exposure to maternal anti\u2010Ro antibodies in the following groups: no CAVB and no prenatal dexamethasone treatment (n = 14), CAVB without prenatal treatment (n = 10), and CAVB with prenatal dexamethasone treatment (n = 16). Domains assessed included intelligence, visual perceptual and visual motor skills, auditory and visual attention, verbal learning and memory, visual memory, executive function, and behavior.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All cohorts scored within the normal range and were not significantly different in terms of intelligence scores, verbal comprehension, perceptional reasoning, working memory, and processing speed. For children with CAVB who were treated prenatally, there were no significant associations between the neurocognitive function scores, the minimal fetal heart rate (range 47\u201380 beats per minute), and either the duration (range 2\u201315 weeks) or dosage (range 56\u2013824 mg) of dexamethasone therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CAVB and transplacental treatment with dexamethasone was not associated with neurocognitive impairment in school\u2010age children. Larger numbers of children are needed to validate our observation, and assessment of other cognitive abilities is warranted.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.38675","type":"journal-article","created":{"date-parts":[[2014,4,22]],"date-time":"2014-04-22T13:58:57Z","timestamp":1398175137000},"page":"2290-2296","source":"Crossref","is-referenced-by-count":29,"title":["Prenatal Anti\u2010Ro Antibody Exposure, Congenital Complete Atrioventricular Heart Block, and High\u2010Dose Steroid Therapy: Impact on Neurocognitive Outcome in School\u2010Age Children"],"prefix":"10.1002","volume":"66","author":[{"given":"E. 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