{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T09:34:12Z","timestamp":1792056852438,"version":"4.4.0"},"reference-count":50,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2014,8,26]],"date-time":"2014-08-26T00:00:00Z","timestamp":1409011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI048097"],"award-info":[{"award-number":["AI048097"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AR060804"],"award-info":[{"award-number":["AR060804"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI007633"],"award-info":[{"award-number":["AI007633"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To assess disease features in\n                      <jats:italic>Sle1.Yaa<\/jats:italic>\n                      mice with genetic interleukin\u20106 (IL\u20106) deficiency.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Sera and tissues were collected from C57BL\/6 (B6),\n                      <jats:italic>Sle1.Yaa<\/jats:italic>\n                      , and\n                      <jats:italic>Sle1.Yaa.IL\u20106<\/jats:italic>\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                      mice and analyzed for various features of disease. Using serum samples, autoantibody specificities were determined by enzyme\u2010linked immunosorbent assay (ELISA) and indirect immunofluorescence, cytokine production was analyzed by Luminex and ELISA, and levels of blood urea nitrogen were determined by ELISA. Renal, lung, and salivary gland tissue sections were evaluated for pathologic changes. Lymphocyte phenotypes, including CD4+ T cell cytokine production, and those of follicular and extrafollicular T helper subsets, germinal center B cells, and plasma cells, were determined using flow cytometry.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>IL\u20106 deficiency not only ameliorated autoantibody production and renal disease in this model, but also effectively reduced inflammation of lungs and salivary glands. Furthermore, IL\u20106 deficiency abrogated differentiation of Th1 and extrafollicular T helper cells, germinal center B cells, and plasma cells in the spleen and eliminated renal T cells with IL\u201017, interferon\u2010\u03b3, and IL\u201021 production potential.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Our findings highlight IL\u20106\u2013mediated T cell aberrations in\n                      <jats:italic>Yaa<\/jats:italic>\n                      \u2010driven autoimmunity and support the concept of therapeutic IL\u20106\/IL\u20106 receptor blockade in systemic lupus erythematosus and Sj\u00f6gren's syndrome by impairing the production of autoantibodies and lymphocytic infiltration of the kidneys, lungs, and salivary glands.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.38716","type":"journal-article","created":{"date-parts":[[2014,5,28]],"date-time":"2014-05-28T16:35:14Z","timestamp":1401294914000},"page":"2521-2531","source":"Crossref","is-referenced-by-count":29,"title":["Interleukin\u20106 Deficiency Corrects Nephritis, Lymphocyte Abnormalities, and Secondary Sj\u00f6gren's Syndrome Features in Lupus\u2010Prone\n                    <i>Sle1.Yaa<\/i>\n                    Mice"],"prefix":"10.1002","volume":"66","author":[{"given":"Jacen S.","family":"Maier\u2010Moore","sequence":"first","affiliation":[{"name":"University of Oklahoma Health Sciences Center and Oklahoma Medical Research Foundation Oklahoma City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher G.","family":"Horton","sequence":"additional","affiliation":[{"name":"University of Oklahoma Health Sciences Center and Oklahoma Medical Research Foundation Oklahoma City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirley A.","family":"Mathews","sequence":"additional","affiliation":[{"name":"Oklahoma Medical Research Foundation Oklahoma City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony W.","family":"Confer","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Oklahoma State University Stillwater"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Lawrence","sequence":"additional","affiliation":[{"name":"Oklahoma Medical Research Foundation Oklahoma City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zijian","family":"Pan","sequence":"additional","affiliation":[{"name":"Oklahoma Medical Research Foundation Oklahoma City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. Mark","family":"Coggeshall","sequence":"additional","affiliation":[{"name":"Oklahoma Medical Research Foundation Oklahoma City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Darise","family":"Farris","sequence":"additional","affiliation":[{"name":"University of Oklahoma Health Sciences Center and Oklahoma Medical Research Foundation Oklahoma City"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,8,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-1-6"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.6.3463"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(97)89206-5"},{"key":"e_1_2_7_5_1","first-page":"S71","article-title":"Role of interleukin\u20106 in the progression of mesangial proliferative glomerulonephritis","volume":"39","author":"Horii Y","year":"1993","journal-title":"Kidney Int"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.19.7547"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V83.9.2570.2570"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6446(97)01164-1"},{"key":"e_1_2_7_9_1","first-page":"1682","article-title":"Bone marrow neutrophilia and suppressed bone turnover in human interleukin\u20106 transgenic mice: a cellular relationship among hematopoietic cells, osteoblasts, and osteoclasts mediated by stromal cells in bone marrow","volume":"147","author":"Kitamura H","year":"1995","journal-title":"Am J Pathol"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-12-192559"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1191\/0961203304lu1023oa"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002281-200209000-00003"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s000110050718"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00191429"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000186996"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.2000.00970.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04753"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.05.009"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1176676"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2013.11.003"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.12.6670"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0603912103"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1124978"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200838138"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2013.09.004"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-201310"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-012513-104728"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60954-X"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2012.01.012"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2009.01582.x"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar3493"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.13.7538"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.6.3913"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20080840"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0904023"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1061964"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.189.11.1747"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.4.2354"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27221"},{"key":"e_1_2_7_40_1","unstructured":"ClinicalTrials.gov. 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