{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T12:41:15Z","timestamp":1780317675771,"version":"3.54.1"},"reference-count":36,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,11,25]],"date-time":"2014-11-25T00:00:00Z","timestamp":1416873600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The Western Norway Regional Health Authority"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Cognitive dysfunction is common in both systemic lupus erythematosus (SLE) and primary Sj\u00f6gren's syndrome (SS). Antibodies against the NR2 subtype of the <jats:italic>N<\/jats:italic>\u2010methyl\u2010<jats:sc>D<\/jats:sc>\u2010aspartate receptor (anti\u2010NR2 antibodies) cause hippocampal atrophy and cognitive impairment in mice and have been associated with memory impairment in both patients with SLE and patients with primary SS. In addition, a reduced volume of hippocampal gray matter has been demonstrated in both SLE and primary SS. This study was undertaken to investigate whether there is a connection between the presence of anti\u2010NR2 antibodies and hippocampal atrophy in human diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty patients with SLE and 50 patients with primary SS underwent clinical examination and cerebral magnetic resonance imaging. Anti\u2010NR2 antibodies in cerebrospinal fluid (CSF) were measured, and hippocampal gray matter volumes were compared between patients who were positive for and those who were negative for anti\u2010NR2 antibodies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with anti\u2010NR2 antibodies in CSF had less hippocampal gray matter than patients without these antibodies. No other differences regarding gray matter volumes in other parts of the brain were identified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The present findings indicate that anti\u2010NR2 antibodies in patients with SLE and primary SS cause neuronal death manifested as reduced hippocampal gray matter, as has been previously demonstrated in mice with autoimmune disease.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.38852","type":"journal-article","created":{"date-parts":[[2014,8,22]],"date-time":"2014-08-22T11:56:43Z","timestamp":1408708603000},"page":"3387-3394","source":"Crossref","is-referenced-by-count":62,"title":["Association of Hippocampal Atrophy With Cerebrospinal Fluid Antibodies Against the NR2 Subtype of the <i>N<\/i>\u2010Methyl\u2010<scp>D<\/scp>\u2010Aspartate Receptor in Patients With Systemic Lupus Erythematosus and Patients With Primary Sj\u00f6gren's Syndrome"],"prefix":"10.1002","volume":"66","author":[{"given":"Maria 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