{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:20:36Z","timestamp":1791181236044,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,11,25]],"date-time":"2014-11-25T00:00:00Z","timestamp":1416873600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the factors associated with cartilage proteoglycan content in patients with rheumatoid arthritis (RA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 32 RA patients received high\u2010field 3T delayed gadolinium\u2010enhanced magnetic resonance imaging of cartilage (dGEMRIC) to determine cartilage proteoglycan content. Measurements were performed in 3 individual cartilage regions (medial, central, and lateral) of metacarpophalangeal (MCP) joints 2 and 3. T1 dGEMRIC values were then related to disease duration, disease activity, anti\u2013citrullinated protein antibody (ACPA) status, rheumatoid factor (RF) status, and C\u2010reactive protein (CRP) level.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>T1 dGEMRIC values did not differ significantly between MCP joints 2 and 3. Intraclass correlation coefficients were high (&gt;0.92) for all 3 cartilage compartments (medial, central, and lateral). T1 dGEMRIC values were significantly lower in RA patients with longer disease duration (\u22653 years) (<jats:italic>P<\/jats:italic> = 0.034 for the central compartment) and those with ACPA positivity (<jats:italic>P<\/jats:italic> = 0.0002 for the central compartment, <jats:italic>P<\/jats:italic> = 0.013 for the lateral compartment). In contrast, no associations were found between cartilage proteoglycan content and disease activity, CRP level, or RF status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Decreased cartilage proteoglycan content in RA patients is associated with disease duration and ACPA positivity but not with actual disease activity, CRP level, or RF status. These data suggest that the cumulative burden of inflammation as well as ACPAs are the determinants of cartilage damage in RA.<\/jats:p><\/jats:sec>","DOI":"10.1002\/art.38862","type":"journal-article","created":{"date-parts":[[2014,9,3]],"date-time":"2014-09-03T14:50:15Z","timestamp":1409755815000},"page":"3283-3288","source":"Crossref","is-referenced-by-count":13,"title":["Brief Report: Anti\u2013Citrullinated Protein Antibody Positivity Correlates With Cartilage Damage and Proteoglycan Levels in Patients With Rheumatoid Arthritis in the Hand Joints"],"prefix":"10.1002","volume":"66","author":[{"given":"Nina","family":"Renner","sequence":"first","affiliation":[{"name":"University Hospital Erlangen Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Kr\u00f6nke","sequence":"additional","affiliation":[{"name":"University Hospital Erlangen Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Rech","sequence":"additional","affiliation":[{"name":"University Hospital Erlangen Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Uder","sequence":"additional","affiliation":[{"name":"University Hospital Erlangen Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf","family":"Janka","sequence":"additional","affiliation":[{"name":"University Hospital Erlangen Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Lauer","sequence":"additional","affiliation":[{"name":"Siemens Healthcare Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominik","family":"Paul","sequence":"additional","affiliation":[{"name":"Siemens Healthcare Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Herz","sequence":"additional","affiliation":[{"name":"University Hospital Erlangen Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Schlechtweg","sequence":"additional","affiliation":[{"name":"University Hospital Erlangen Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friedrich Frank","family":"Hennig","sequence":"additional","affiliation":[{"name":"University Hospital Erlangen Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Schett","sequence":"additional","affiliation":[{"name":"University Hospital Erlangen Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f6tz","family":"Welsch","sequence":"additional","affiliation":[{"name":"University Hospital Erlangen Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,11,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1004965"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2012.153"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-013-0366-7"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-202958"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-201620"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar2592"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2012.05.021"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.33352"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-202850"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/02841851.2010.510482"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22316"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.090352"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2007.11.002"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27584"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780380107"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.21091"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2009.03.022"},{"key":"e_1_2_7_19_1","first-page":"336","article-title":"Mechanisms of cartilage degradation in inflammatory arthritis: interaction between chondrocytes and immunoglobulin G","volume":"20","author":"Saura R","year":"1993","journal-title":"J Rheumatol"}],"container-title":["Arthritis &amp; 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