{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T02:32:48Z","timestamp":1791340368733,"version":"4.3.1"},"reference-count":51,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,12,27]],"date-time":"2014-12-27T00:00:00Z","timestamp":1419638400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["P01-052915"],"award-info":[{"award-number":["P01-052915"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"crossref","award":["APP1024879"],"award-info":[{"award-number":["APP1024879"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatology"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To use high\u2010density genotyping to investigate the genetic associations of acute anterior uveitis (AAU) in patients with and those without ankylosing spondylitis (AS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We genotyped samples from 1,711 patients with AAU (either primary or combined with AS), 2,339 AS patients without AAU, and 10,000 control subjects on an Illumina Immunochip Infinium microarray. We also used data for AS patients from previous genome\u2010wide association studies to investigate the AS risk locus\n                      <jats:italic>ANTXR2<\/jats:italic>\n                      for its putative effect in AAU.\n                      <jats:italic>ANTXR2<\/jats:italic>\n                      expression in mouse eyes was investigated by real\u2010time quantitative reverse transcription\u2013polymerase chain reaction.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A comparison between all patients with AAU and healthy control subjects showed strong association over\n                      <jats:italic>HLA\u2013B<\/jats:italic>\n                      , corresponding to the\n                      <jats:italic>HLA\u2013B27<\/jats:italic>\n                      tag single\u2010nucleotide polymorphism rs116488202. The association of 3 non\u2013major histocompatibility complex loci,\n                      <jats:italic>IL23R<\/jats:italic>\n                      , the intergenic region 2p15, and\n                      <jats:italic>ERAP1<\/jats:italic>\n                      , reached genome\u2010wide significance (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 5 \u00d7 10\n                      <jats:sup>\u22128<\/jats:sup>\n                      ). Five loci harboring the immune\u2010related genes\n                      <jats:italic>IL10\u2013IL19<\/jats:italic>\n                      ,\n                      <jats:italic>IL18R1\u2013IL1R1<\/jats:italic>\n                      ,\n                      <jats:italic>IL6R<\/jats:italic>\n                      , the chromosome 1q32 locus harboring\n                      <jats:italic>KIF21B<\/jats:italic>\n                      , as well as the eye\u2010related gene\n                      <jats:italic>EYS<\/jats:italic>\n                      , were also associated, reaching a suggestive level of significance (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 5 \u00d7 10\n                      <jats:sup>\u22126<\/jats:sup>\n                      ). Several previously confirmed AS associations demonstrated significant differences in effect size between AS patients with AAU and AS patients without AAU.\n                      <jats:italic>ANTXR2<\/jats:italic>\n                      expression varied across eye compartments.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      These findings of both novel AAU\u2010specific associations and associations shared with AS demonstrate overlapping but also distinct genetic susceptibility loci for AAU and AS. The associations in\n                      <jats:italic>IL10<\/jats:italic>\n                      and\n                      <jats:italic>IL18R1<\/jats:italic>\n                      are shared with inflammatory bowel disease, suggesting common etiologic pathways.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/art.38873","type":"journal-article","created":{"date-parts":[[2014,9,8]],"date-time":"2014-09-08T15:53:21Z","timestamp":1410191601000},"page":"140-151","source":"Crossref","is-referenced-by-count":134,"title":["Genetic Dissection of Acute Anterior Uveitis Reveals Similarities and Differences in Associations Observed With Ankylosing Spondylitis"],"prefix":"10.1002","volume":"67","author":[{"given":"Philip C.","family":"Robinson","sequence":"first","affiliation":[{"name":"University of Queensland Diamantina Institute, Translational Research Institute and Princess Alexandra Hospital, Woolloongabba Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodora A. 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